Clavucure
Generic Name
Amoxicillin 250 mg and Clavulanic Acid 125 mg Tablet
Manufacturer
Acme Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| clavucure 250 mg tablet | ৳ 34.00 | ৳ 238.00 |
Description
Overview of the medicine
Clavucure 250 mg Tablet is a broad-spectrum antibiotic containing Amoxicillin and Clavulanic Acid, used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
One Clavucure 250 mg tablet three times a day (every 8 hours) for 7-10 days, or as directed by physician.
Elderly
No specific dose adjustment needed unless severe renal impairment.
Renal_impairment
Dose adjustment required based on creatinine clearance.
How to Take
Take with food to minimize potential gastrointestinal intolerance. Swallow the tablet whole with a glass of water.
Mechanism of Action
Amoxicillin inhibits bacterial cell wall synthesis. Clavulanic acid is a beta-lactamase inhibitor, protecting Amoxicillin from degradation by beta-lactamase enzymes produced by resistant bacteria.
Pharmacokinetics
Onset
Rapid, within 30 minutes to 1 hour for antibacterial action.
Excretion
Primarily renal (glomerular filtration and tubular secretion) for Amoxicillin, both renal and non-renal for Clavulanic acid.
Half life
Approximately 1-1.5 hours for both components.
Absorption
Well absorbed orally, enhanced by food. Peak plasma concentrations reached within 1-2 hours.
Metabolism
Amoxicillin undergoes limited metabolism; Clavulanic acid is extensively metabolized.
Side Effects
Contraindications
- History of hypersensitivity to penicillin or other beta-lactam antibiotics.
- History of amoxicillin/clavulanate-associated jaundice or hepatic dysfunction.
Drug Interactions
Warfarin
May increase INR; monitor coagulation parameters.
Probenecid
Increases and prolongs Amoxicillin blood levels.
Allopurinol
May increase incidence of skin rash.
Methotrexate
May increase methotrexate toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset, electrolyte imbalance, crystalluria. Treatment is symptomatic and supportive. Hemodialysis can remove Amoxicillin/Clavulanate from circulation.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- History of hypersensitivity to penicillin or other beta-lactam antibiotics.
- History of amoxicillin/clavulanate-associated jaundice or hepatic dysfunction.
Drug Interactions
Warfarin
May increase INR; monitor coagulation parameters.
Probenecid
Increases and prolongs Amoxicillin blood levels.
Allopurinol
May increase incidence of skin rash.
Methotrexate
May increase methotrexate toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset, electrolyte imbalance, crystalluria. Treatment is symptomatic and supportive. Hemodialysis can remove Amoxicillin/Clavulanate from circulation.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied and clinically proven for its efficacy and safety in various bacterial infections.
Lab Monitoring
- Periodic assessment of renal, hepatic, and hematopoietic function during prolonged therapy.
- Monitor INR in patients on anticoagulants.
Doctor Notes
- Counsel patients on the importance of completing the full antibiotic course.
- Be vigilant for signs of C. difficile infection or allergic reactions.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Take with food to minimize stomach upset.
- Report any signs of allergic reaction or severe diarrhea.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not take a double dose.
Driving Precautions
May cause dizziness in some patients; use caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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