Clavucure
Generic Name
Amoxicillin and Clavulanic Acid
Manufacturer
Local Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| clavucure 500 mg tablet | ৳ 55.00 | ৳ 385.00 |
Description
Overview of the medicine
Clavucure-500-mg-tablet is a broad-spectrum antibiotic combination of amoxicillin and clavulanic acid, used to treat various bacterial infections, including those caused by beta-lactamase producing bacteria.
Uses & Indications
Dosage
Adults
The usual adult dose is 500 mg amoxicillin/125 mg clavulanic acid every 8 hours, or 875 mg amoxicillin/125 mg clavulanic acid every 12 hours, depending on the severity of the infection.
Elderly
No specific dose adjustment is required in elderly patients with normal renal function. Dose should be adjusted in case of renal impairment.
Renal_impairment
Dose adjustment is necessary based on creatinine clearance. For CrCl 10-30 mL/min, 500 mg/125 mg every 12 hours. For CrCl <10 mL/min, 500 mg/125 mg every 24 hours.
How to Take
Take Clavucure-500-mg-tablet orally at the start of a meal to minimize potential gastrointestinal intolerance and to optimize absorption.
Mechanism of Action
Amoxicillin inhibits bacterial cell wall synthesis, leading to cell lysis and death. Clavulanic acid inhibits beta-lactamase enzymes, which are produced by some bacteria to break down amoxicillin, thus extending amoxicillin's antibacterial spectrum.
Pharmacokinetics
Onset
Peak plasma concentrations are usually achieved within 1 to 2 hours after oral administration.
Excretion
Both components are primarily excreted by the kidneys, with amoxicillin largely excreted unchanged.
Half life
The elimination half-life is approximately 1 to 1.5 hours for amoxicillin and about 1 hour for clavulanic acid.
Absorption
Both amoxicillin and clavulanic acid are well absorbed from the gastrointestinal tract after oral administration. Absorption is optimized when taken at the start of a meal.
Metabolism
Amoxicillin is partially metabolized, while clavulanic acid is extensively metabolized.
Side Effects
Contraindications
- History of hypersensitivity to amoxicillin, clavulanic acid, or any other penicillin antibiotic
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to any beta-lactam antibiotic (e.g., cephalosporins)
- History of cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanic acid therapy
Drug Interactions
Allopurinol
Increased incidence of rash with concomitant use.
Methotrexate
May increase methotrexate toxicity; monitor for signs of toxicity.
Oral contraceptives
May reduce the efficacy of oral contraceptives; advise additional contraception.
Warfarin and other oral anticoagulants
May prolong prothrombin time; monitor INR closely.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include gastrointestinal effects (e.g., abdominal pain, vomiting, diarrhea) and fluid and electrolyte imbalance. Rarely, renal impairment or convulsions may occur. Treatment is symptomatic and supportive, and hemodialysis may be used to remove the drug from circulation.
Pregnancy & Lactation
Pregnancy Category B. While studies have not shown harm, use during pregnancy should only be if clearly needed. Both amoxicillin and clavulanic acid are excreted into breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- History of hypersensitivity to amoxicillin, clavulanic acid, or any other penicillin antibiotic
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to any beta-lactam antibiotic (e.g., cephalosporins)
- History of cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanic acid therapy
Drug Interactions
Allopurinol
Increased incidence of rash with concomitant use.
Methotrexate
May increase methotrexate toxicity; monitor for signs of toxicity.
Oral contraceptives
May reduce the efficacy of oral contraceptives; advise additional contraception.
Warfarin and other oral anticoagulants
May prolong prothrombin time; monitor INR closely.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include gastrointestinal effects (e.g., abdominal pain, vomiting, diarrhea) and fluid and electrolyte imbalance. Rarely, renal impairment or convulsions may occur. Treatment is symptomatic and supportive, and hemodialysis may be used to remove the drug from circulation.
Pregnancy & Lactation
Pregnancy Category B. While studies have not shown harm, use during pregnancy should only be if clearly needed. Both amoxicillin and clavulanic acid are excreted into breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Expired for generic versions
WHO Essential Medicine
YesClinical Trials
Amoxicillin-clavulanic acid has undergone extensive clinical trials demonstrating its efficacy and safety across a wide range of bacterial infections. Ongoing post-marketing surveillance and studies continue to monitor its long-term effects and resistance patterns.
Lab Monitoring
- Liver function tests (LFTs) periodically in patients with pre-existing hepatic dysfunction or during prolonged therapy.
- Renal function tests, especially in elderly patients or those with known renal impairment.
Doctor Notes
- Prior to prescribing, inquire about previous hypersensitivity reactions to penicillins or cephalosporins.
- Consider microbiological sampling and susceptibility testing where appropriate.
- Advise patients about the potential for Clostridium difficile-associated diarrhea, which can occur up to two months after antibiotic treatment.
Patient Guidelines
- Complete the entire prescribed course of medicine, even if you feel better, to prevent recurrence and antibiotic resistance.
- Take the tablet with a meal to reduce the chance of stomach upset.
- Report any severe or persistent side effects, especially severe diarrhea or allergic reactions, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine can occasionally cause dizziness or headache. Patients should be aware of their reaction to the drug before driving or operating machinery.
Lifestyle Advice
- Stay well-hydrated by drinking plenty of fluids throughout the course of treatment.
- Avoid alcohol if experiencing gastrointestinal upset, as it may worsen symptoms.
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