Clofenac

For rectal administration only. Insert the suppository high into the rectum, pointed end first, after ensuring the bowel is empty. Do not take by mouth.

Diclofenac works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever. By reducing prostaglandin production, diclofenac alleviates these symptoms.

• Known hypersensitivity to diclofenac or other NSAIDs (e.g., aspirin-induced asthma)
• Active gastrointestinal ulceration, bleeding, or perforation
• Severe heart failure
• Severe renal or hepatic impairment
• Third trimester of pregnancy
• Proctitis or history of rectal bleeding (for suppositories)

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Symptoms include lethargy, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, hypertension, acute renal failure, respiratory depression, and coma. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if recent oral ingestion, but less relevant for suppositories. Monitor renal function, liver enzymes, and electrolyte levels.

Pregnancy: Avoid in the third trimester due to risk of premature closure of the fetal ductus arteriosus. Use only if clearly needed in first and second trimesters, and at the lowest effective dose for the shortest possible duration. Lactation: Diclofenac is excreted in breast milk in small amounts; generally considered compatible with breastfeeding with caution, but monitor infant for adverse effects.

• Known hypersensitivity to diclofenac or other NSAIDs (e.g., aspirin-induced asthma)
• Active gastrointestinal ulceration, bleeding, or perforation
• Severe heart failure
• Severe renal or hepatic impairment
• Third trimester of pregnancy
• Proctitis or history of rectal bleeding (for suppositories)

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Symptoms include lethargy, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, hypertension, acute renal failure, respiratory depression, and coma. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if recent oral ingestion, but less relevant for suppositories. Monitor renal function, liver enzymes, and electrolyte levels.

Pregnancy: Avoid in the third trimester due to risk of premature closure of the fetal ductus arteriosus. Use only if clearly needed in first and second trimesters, and at the lowest effective dose for the shortest possible duration. Lactation: Diclofenac is excreted in breast milk in small amounts; generally considered compatible with breastfeeding with caution, but monitor infant for adverse effects.