Medicine Information

Clorocef

Name: Clorocef
Brand: Clorocef

Pediatric Drop / Oral Suspension125 mg per 5 mLAntibioticsATC: J01DC04

Generic Name

clorocef-125-mg-pediatric-drop

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
clorocef 125 mg pediatric drop	৳ 130.00	N/A

Description

Overview of the medicine

Clorocef 125 mg Pediatric Drop is a cephalosporin antibiotic used to treat various bacterial infections in children, such as ear infections, throat infections, lung infections, and skin infections.

Uses & Indications

Otitis media (middle ear infection)

Pharyngitis and Tonsillitis (throat infections)

Lower respiratory tract infections (e.g., bronchitis, pneumonia)

Upper respiratory tract infections (e.g., sinusitis)

Skin and soft tissue infections

Urinary tract infections

Dosage

Adults

Not typically used for adults in this specific 'pediatric drop' form. Adult dosage for Cefaclor is generally 250-500 mg every 8 hours.

Elderly

As per adult dosage, with careful consideration for renal function. Dosage adjustment may be necessary.

Renal_impairment

Dosage adjustment is required based on creatinine clearance. For CrCl 10-50 mL/min, administer 50% of the usual dose. For CrCl <10 mL/min, administer 25% of the usual dose.

How to Take

Clorocef Pediatric Drop should be administered orally, with or without food. Use the provided dropper for accurate measurement. Shake the suspension well before each use. Complete the full course of treatment as prescribed by the physician.

Mechanism of Action

Cefaclor is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved within 30-60 minutes.

Excretion

Mainly excreted by the kidneys through glomerular filtration and tubular secretion. Approximately 60-85% of the dose is excreted unchanged in the urine within 8 hours.

Half life

Approximately 0.5-1 hour.

Absorption

Rapidly and almost completely absorbed after oral administration. Food may delay absorption but not significantly reduce the extent.

Metabolism

Limited hepatic metabolism; primarily excreted as unchanged drug.

Side Effects

Contraindications

Known hypersensitivity to cefaclor or other cephalosporin antibiotics.
History of severe hypersensitivity reaction to penicillin or other beta-lactam antibiotics.

Drug Interactions

Probenecid

Increases cefaclor plasma levels and prolongs its half-life by inhibiting renal tubular secretion.

Aminoglycosides

Concurrent use may increase the risk of nephrotoxicity.

Warfarin and other oral anticoagulants

May increase the anticoagulant effect, requiring close monitoring of prothrombin time (INR).

Storage

Store the unreconstituted powder at room temperature (below 25°C), away from light and moisture. Do not freeze. Store the reconstituted suspension in a refrigerator (2-8°C) and discard any unused portion after 14 days.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. Management primarily involves gastric lavage if ingestion is recent, and supportive care. Hemodialysis is generally not effective. Contact a poison control center immediately.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, use in pregnancy should only be if clearly needed. Cefaclor is excreted in low concentrations in human milk; caution should be exercised when administered to a nursing mother.

Side Effects

Contraindications

Known hypersensitivity to cefaclor or other cephalosporin antibiotics.
History of severe hypersensitivity reaction to penicillin or other beta-lactam antibiotics.

Drug Interactions

Probenecid

Increases cefaclor plasma levels and prolongs its half-life by inhibiting renal tubular secretion.

Aminoglycosides

Concurrent use may increase the risk of nephrotoxicity.

Warfarin and other oral anticoagulants

May increase the anticoagulant effect, requiring close monitoring of prothrombin time (INR).

Storage

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

15 mL bottle30 mL bottle

Shelf Life

Unreconstituted powder: 24 months. Reconstituted suspension: 14 days when stored in a refrigerator (2-8°C).

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA/FDA

Patent Status

Off-patent

Clinical Trials

Cefaclor has undergone extensive clinical trials demonstrating its efficacy and safety in treating various bacterial infections, particularly in pediatric populations, across numerous studies since its introduction.

Lab Monitoring

Periodical monitoring of renal function is advised during prolonged therapy.
Complete blood count (CBC) may be monitored during extended treatment periods.

Doctor Notes

Always inquire about a history of penicillin allergy before prescribing cefaclor due to potential cross-reactivity.
Adjust dosage for patients with renal impairment based on creatinine clearance.
Educate parents/caregivers on the importance of completing the full course of treatment and proper administration using the provided dropper.

Patient Guidelines

Complete the entire course of the antibiotic as prescribed by your doctor, even if symptoms improve.
Do not share this medication with others, as it may not be suitable for their condition.
Consult your doctor immediately if you experience severe diarrhea, rash, or any other unusual side effects.

Missed Dose Advice

If a dose is missed, administer it as soon as remembered. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one.

Driving Precautions

Clorocef generally does not affect the ability to drive or operate machinery. However, some individuals may experience dizziness, so caution is advised until you know how the medication affects you.