Medicine Information

Clorocef

Name: Clorocef
Brand: Clorocef
Rating: 4.5 (117 reviews)

Capsule250 mgAntibacterial (systemic use)ATC: J01DC04

Generic Name

Cefaclor

Manufacturer

ACME Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
clorocef 250 mg capsule	৳ 22.00	৳ 88.00

Description

Overview of the medicine

Clorocef 250 mg capsule contains Cefaclor, a broad-spectrum second-generation cephalosporin antibiotic. It is used to treat various bacterial infections susceptible to Cefaclor.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia)

Otitis media (middle ear infection)

Sinusitis

Pharyngitis and tonsillitis

Urinary tract infections (e.g., cystitis, pyelonephritis)

Skin and soft tissue infections

Dosage

Adults

Usually 250 mg every 8 hours. For more severe infections or those caused by less susceptible organisms, doses may be doubled. Maximum dose 4 g/day.

Elderly

No specific dosage adjustment is usually necessary unless there is severe renal impairment.

Renal_impairment

For severe renal impairment (creatinine clearance <10 mL/min), initial dose 250-500 mg followed by 250 mg every 12 hours. Careful clinical and laboratory monitoring is recommended.

How to Take

Clorocef capsules should be swallowed whole with water. Can be taken with or without food. Taking it with food may help reduce gastrointestinal upset.

Mechanism of Action

Cefaclor is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.

Pharmacokinetics

Onset

Peak plasma concentrations are usually attained within 0.5 to 1 hour.

Excretion

Primarily excreted unchanged by the kidneys, with about 60-85% of the dose recovered in the urine within 8 hours.

Half life

Approximately 0.6 to 1 hour in individuals with normal renal function.

Absorption

Rapidly and well absorbed from the gastrointestinal tract after oral administration. Food may delay absorption but does not affect the total amount absorbed.

Metabolism

Minimal metabolism occurs.

Side Effects

Contraindications

Hypersensitivity to Cefaclor or any other cephalosporin antibiotics.
History of severe hypersensitivity reactions to penicillin (due to potential cross-reactivity).

Drug Interactions

Probenecid

Increases plasma concentrations and prolongs the half-life of Cefaclor.

Aminoglycosides

Concurrent use with some cephalosporins has been associated with nephrotoxicity.

Oral Anticoagulants (e.g., Warfarin)

May enhance the anticoagulant effect; INR monitoring recommended.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. Management is symptomatic and supportive, including gastric lavage and activated charcoal if ingestion is recent.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, use in pregnancy should be only if clearly needed. Cefaclor is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules20 capsules (2x10)

Shelf Life

24 months from the date of manufacture

Availability

Pharmacies, hospitals

Approval Status

Approved by regulatory authorities in many countries including DGDA (Bangladesh)

Patent Status

Patent expired

Clinical Trials

Cefaclor has been extensively studied in various clinical trials demonstrating its efficacy and safety in treating a wide range of bacterial infections. Ongoing research focuses on antibiotic resistance patterns.

Lab Monitoring

Complete Blood Count (CBC) if used for prolonged periods.
Renal function tests (e.g., creatinine, BUN) in patients with pre-existing renal impairment or during prolonged high-dose therapy.

Doctor Notes

Cefaclor is generally well-tolerated. Counsel patients on the importance of completing the full course. Monitor for hypersensitivity reactions, especially in penicillin-allergic patients. Adjust dose in severe renal impairment.
Consider stool sample testing for CDAD if persistent diarrhea occurs.

Patient Guidelines

Take the full course of medicine as prescribed by your doctor, even if you feel better.
Do not share your medicine with others.
Inform your doctor about any history of allergies, especially to antibiotics.
Contact your doctor if side effects persist or worsen.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Cefaclor may cause dizziness in some patients. Patients should be advised to exercise caution before driving or operating machinery until they know how Cefaclor affects them.