Colipan
Generic Name
Hyoscine Butylbromide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| colipan 10 mg tablet | ৳ 3.00 | N/A |
Description
Overview of the medicine
Colipan 10 mg tablet contains Hyoscine Butylbromide, an antispasmodic agent used to relieve cramps or spasms of the stomach, intestines, and bladder, often associated with irritable bowel syndrome (IBS) or menstrual pain.
Uses & Indications
Dosage
Adults
Oral: 10-20 mg three to five times daily. Max: 100 mg/day.
Elderly
No specific dose adjustment required, but use with caution due to increased anticholinergic sensitivity.
Renal_impairment
No specific dose adjustment necessary, but monitor for adverse effects.
How to Take
Oral administration. Tablets should be swallowed whole with water, before or after meals.
Mechanism of Action
Hyoscine Butylbromide is an anticholinergic agent that specifically targets muscarinic receptors in the smooth muscles of the gastrointestinal and genitourinary tracts. By blocking these receptors, it reduces muscle spasms and provides symptomatic relief from cramps and pain.
Pharmacokinetics
Onset
Oral: 15-30 minutes; IV: Immediate.
Excretion
Mainly via feces; a small portion via urine.
Half life
Approximately 5 hours (elimination half-life after IV administration).
Absorption
Poorly absorbed from the gastrointestinal tract (typically <1% bioavailability).
Metabolism
Primarily hepatic metabolism, mostly excreted unchanged.
Side Effects
Contraindications
- Myasthenia gravis
- Megacolon
- Paralytic ileus or intestinal obstruction
- Prostatic enlargement with urinary retention
- Narrow-angle glaucoma
- Tachycardia or tachyarrhythmia
- Hypersensitivity to Hyoscine Butylbromide or any excipients
Drug Interactions
Beta-agonists
May increase heart rate.
Antihistamines
Increased anticholinergic effects.
Tricyclic antidepressants
Increased anticholinergic effects.
Dopamine antagonists (e.g., Metoclopramide)
Reduced effect of both drugs.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dry mouth, visual disturbances, tachycardia, urinary retention, and skin redness. Treatment is symptomatic and supportive. Physostigmine may be used in severe cases.
Pregnancy & Lactation
Use during pregnancy and lactation is generally not recommended unless clearly necessary. Consult a doctor. Category C for pregnancy.
Side Effects
Contraindications
- Myasthenia gravis
- Megacolon
- Paralytic ileus or intestinal obstruction
- Prostatic enlargement with urinary retention
- Narrow-angle glaucoma
- Tachycardia or tachyarrhythmia
- Hypersensitivity to Hyoscine Butylbromide or any excipients
Drug Interactions
Beta-agonists
May increase heart rate.
Antihistamines
Increased anticholinergic effects.
Tricyclic antidepressants
Increased anticholinergic effects.
Dopamine antagonists (e.g., Metoclopramide)
Reduced effect of both drugs.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dry mouth, visual disturbances, tachycardia, urinary retention, and skin redness. Treatment is symptomatic and supportive. Physostigmine may be used in severe cases.
Pregnancy & Lactation
Use during pregnancy and lactation is generally not recommended unless clearly necessary. Consult a doctor. Category C for pregnancy.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, MHRA, DGDA)
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have established the efficacy and safety of Hyoscine Butylbromide in treating various spasmodic conditions. Recent studies focus on its role in IBS management and acute abdominal pain.
Lab Monitoring
- No routine lab monitoring typically required.
- Monitor for signs of urinary retention in elderly patients or those with prostatic hypertrophy.
Doctor Notes
- Counsel patients on potential anticholinergic side effects, especially dry mouth and blurred vision.
- Caution in elderly and patients with prostatic hypertrophy due to risk of urinary retention.
- Not effective for pain caused by inflammation or obstruction, only for spasm.
- Advise patients that onset of action is rapid for injection but slower for oral tablets.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Avoid driving or operating machinery if you experience blurred vision or dizziness.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause blurred vision or dizziness. Patients should be advised not to drive or operate machinery if they experience these effects.
Lifestyle Advice
- Maintain adequate hydration.
- For IBS, consider dietary modifications as advised by a healthcare professional.
- Avoid alcohol, as it may exacerbate side effects.
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