D-Revive
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| d revive 2000 iu tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
D-Revive 2000 IU Tablet is a Vitamin D3 (Cholecalciferol) supplement used to prevent and treat vitamin D deficiency. It helps the body absorb calcium and phosphorus, crucial for maintaining strong bones and teeth, and supports overall immune function.
Uses & Indications
Dosage
Adults
2000 IU daily or as directed by physician for maintenance; higher doses for deficiency treatment.
Elderly
Similar to adult dosage, but may require closer monitoring due to potential malabsorption.
Renal_impairment
Use with caution; active form (calcitriol) may be preferred in severe cases. Consult physician.
How to Take
Orally, preferably with a meal to enhance absorption, as it is a fat-soluble vitamin.
Mechanism of Action
Cholecalciferol (Vitamin D3) is a precursor that is metabolized in the liver to 25-hydroxycholecalciferol (calcifediol) and then in the kidneys to the active form, 1,25-dihydroxycholecalciferol (calcitriol). Calcitriol acts as a hormone to regulate calcium and phosphate homeostasis, promoting their absorption from the gut, reabsorption in the kidneys, and mobilization from bone.
Pharmacokinetics
Onset
Days to weeks for clinical effect, peak blood levels in 4-5 hours.
Excretion
Mainly in bile and feces; small amounts in urine.
Half life
Approximately 15-20 days for calcifediol (25-hydroxyvitamin D).
Absorption
Well absorbed from the small intestine, especially with fatty meals.
Metabolism
Primarily in the liver (to calcifediol) and kidneys (to calcitriol).
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any component
- Hypercalcemia
- Hypervitaminosis D
- Severe renal impairment (without proper monitoring)
Drug Interactions
Corticosteroids
May reduce vitamin D effects.
Thiazide diuretics
May increase risk of hypercalcemia.
Phenytoin, Barbiturates
May increase vitamin D metabolism, reducing its effects.
Antacids containing aluminum
May increase aluminum absorption, especially in renal impairment.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypercalcemia (excess calcium in blood), nausea, vomiting, loss of appetite, weakness, constipation, and confusion. In severe cases, it can lead to kidney damage. Treatment involves discontinuing the supplement, hydration, and medical management of hypercalcemia.
Pregnancy & Lactation
Safe during pregnancy and lactation at recommended doses, but excessive doses should be avoided. Consult a healthcare professional before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Pharmacies, drugstores, online
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic (Patent expired)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials support the efficacy of Cholecalciferol in treating and preventing vitamin D deficiency, improving bone mineral density, and reducing fracture risk, especially in the elderly.
Lab Monitoring
- Serum 25-hydroxyvitamin D levels
- Serum calcium levels
- Serum phosphate levels
- Renal function tests (e.g., creatinine)
Doctor Notes
- Assess baseline vitamin D levels before initiating high-dose therapy.
- Monitor serum calcium and 25(OH)D levels periodically during treatment.
- Advise patients on dietary sources and safe sun exposure.
- Individualize dosage based on patient's deficiency status and clinical response.
Patient Guidelines
- Take exactly as prescribed or directed.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications and supplements you are taking.
- Report any signs of hypercalcemia (e.g., excessive thirst, frequent urination) to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cholecalciferol is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Combine with adequate sunlight exposure (if possible and safe).
- Maintain a balanced diet rich in calcium and phosphorus.
- Engage in regular weight-bearing exercise for bone health.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
Related
Medicines
Explore similar medicines to find the best option for your healthcare needs.
Exomi MUPS
Square Pharmaceuticals Ltd.
Azelec
Square Pharmaceuticals Ltd.
EuroORS
Euro Pharma Ltd.
Exler
Incepta Pharmaceuticals
Axxo
Square Pharmaceuticals Ltd.
Exopan
Square Pharmaceuticals Ltd.
Expreso Plus
Pharma Beximco
Azi S
Square Pharmaceuticals Ltd.
Evoloxin
Incepta Pharmaceuticals Ltd.
Axovit
Reputable Pharma Ltd.