D-Shine
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Unimed Unihealth Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| d shine 2000 iu tablet | ৳ 2.30 | ৳ 23.00 |
Description
Overview of the medicine
D-Shine 2000 IU Tablet contains Cholecalciferol (Vitamin D3), an essential vitamin that helps the body absorb calcium and phosphorus, crucial for maintaining strong bones and teeth. It is used to prevent and treat Vitamin D deficiency.
Uses & Indications
Dosage
Adults
For Vitamin D deficiency: 2000 IU daily or as directed by physician. For maintenance, 800-2000 IU daily.
Elderly
Similar to adult dosage, but often higher needs may be present. Consult a physician.
Renal_impairment
Use with caution, monitoring calcium and phosphate levels. Not usually contraindicated, but active vitamin D forms might be preferred in severe cases.
How to Take
Orally, with or without food. Some sources suggest taking it with a fatty meal to enhance absorption.
Mechanism of Action
Cholecalciferol (Vitamin D3) is converted in the liver to 25-hydroxyvitamin D (calcifediol) and then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol), the active form. Calcitriol acts as a hormone, regulating calcium and phosphate levels by promoting absorption from the gut, reabsorption in the kidneys, and bone mineralization.
Pharmacokinetics
Onset
Therapeutic effects observed within days to weeks.
Excretion
Primarily excreted in bile and feces, a small amount in urine.
Half life
Approximately 15 days for cholecalciferol; 25-hydroxyvitamin D has a half-life of 2-3 weeks; 1,25-dihydroxyvitamin D has a half-life of 4-6 hours.
Absorption
Well absorbed from the small intestine, especially in the presence of fat.
Metabolism
Converted in the liver to 25-hydroxyvitamin D and then in the kidneys to 1,25-dihydroxyvitamin D.
Side Effects
Contraindications
- Hypercalcemia (high calcium levels)
- Hypervitaminosis D (Vitamin D toxicity)
- Severe renal impairment with hyperphosphatemia
Drug Interactions
Corticosteroids
May reduce Vitamin D effects.
Thiazide diuretics
May increase the risk of hypercalcemia.
Digitalis glycosides
May increase the risk of arrhythmias due to hypercalcemia.
Anticonvulsants (e.g., phenytoin, barbiturates)
May increase Vitamin D metabolism, reducing its effectiveness.
Cholestyramine, Colestipol, Orlistat, Mineral oil
May impair absorption of Vitamin D.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, weakness, polyuria, polydipsia, confusion, kidney stones). Treatment involves discontinuing Vitamin D, low calcium diet, hydration, and corticosteroids in severe cases.
Pregnancy & Lactation
Generally considered safe and often recommended in recommended doses during pregnancy and lactation for both maternal and infant health. Excessive doses should be avoided. Consult a doctor.
Side Effects
Contraindications
- Hypercalcemia (high calcium levels)
- Hypervitaminosis D (Vitamin D toxicity)
- Severe renal impairment with hyperphosphatemia
Drug Interactions
Corticosteroids
May reduce Vitamin D effects.
Thiazide diuretics
May increase the risk of hypercalcemia.
Digitalis glycosides
May increase the risk of arrhythmias due to hypercalcemia.
Anticonvulsants (e.g., phenytoin, barbiturates)
May increase Vitamin D metabolism, reducing its effectiveness.
Cholestyramine, Colestipol, Orlistat, Mineral oil
May impair absorption of Vitamin D.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, weakness, polyuria, polydipsia, confusion, kidney stones). Treatment involves discontinuing Vitamin D, low calcium diet, hydration, and corticosteroids in severe cases.
Pregnancy & Lactation
Generally considered safe and often recommended in recommended doses during pregnancy and lactation for both maternal and infant health. Excessive doses should be avoided. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, supermarkets, online stores
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support the efficacy and safety of Cholecalciferol in treating and preventing Vitamin D deficiency and related bone disorders. Ongoing research explores its role in other health conditions.
Lab Monitoring
- Serum 25-hydroxyvitamin D levels
- Serum calcium levels
- Serum phosphate levels
- Renal function (creatinine)
Doctor Notes
- Advise patients on the importance of dietary sources and safe sun exposure.
- Monitor serum 25(OH)D, calcium, and phosphate levels periodically, especially in patients with pre-existing conditions or on high doses.
- Educate about symptoms of hypercalcemia.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Ensure adequate dietary calcium intake.
- Report any symptoms of hypercalcemia (e.g., persistent nausea, vomiting, frequent urination).
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
No known adverse effects on driving ability.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and Vitamin D.
- Regular sun exposure (10-30 minutes, 2-3 times a week, depending on skin type and time of day) can help natural Vitamin D production.
- Engage in regular weight-bearing exercise for bone health.
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