D-Shine
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| d shine 20000 iu capsule | ৳ 19.00 | ৳ 190.00 |
Description
Overview of the medicine
D-Shine 20000 IU Capsule is a vitamin D3 supplement used to treat and prevent vitamin D deficiency, which can lead to various health problems including bone weakness (osteoporosis), rickets, and osteomalacia. It plays a crucial role in calcium absorption and bone mineralization.
Uses & Indications
Dosage
Adults
For severe vitamin D deficiency, typically 20,000 IU once weekly for 7-10 weeks, followed by maintenance dose as per physician's advice.
Elderly
Similar to adult dosage, but often with careful monitoring of vitamin D and calcium levels.
Renal_impairment
Use with caution and monitor calcium and phosphate levels; active vitamin D metabolites may be preferred in severe renal impairment.
How to Take
Take orally, preferably with a main meal containing fat to enhance absorption.
Mechanism of Action
Cholecalciferol (Vitamin D3) is converted to its active form, calcitriol, in the liver and kidneys. Calcitriol then acts as a hormone to regulate calcium and phosphate metabolism, promoting calcium absorption from the gut, facilitating bone mineralization, and affecting immune function.
Pharmacokinetics
Onset
Therapeutic effects are typically observed after several days to weeks of regular administration.
Excretion
Excreted primarily in the bile and feces, with a small amount excreted in urine.
Half life
Circulating half-life of 25(OH)D is about 2-3 weeks, while that of 1,25(OH)2D is a few hours.
Absorption
Readily absorbed from the gastrointestinal tract, especially in the presence of bile salts and dietary fat.
Metabolism
Metabolized in the liver to 25-hydroxyvitamin D (calcidiol) and then in the kidneys to the active form, 1,25-dihydroxyvitamin D (calcitriol).
Side Effects
Contraindications
- Hypercalcemia
- Hypervitaminosis D
- Severe renal impairment
Drug Interactions
Thiazide diuretics
May increase the risk of hypercalcemia.
Phenytoin, Barbiturates
May accelerate the metabolism of vitamin D, reducing its effects.
Bile acid sequestrants (e.g., Cholestyramine)
May impair the absorption of vitamin D.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, weakness, constipation, confusion), kidney damage, and soft tissue calcification. Treatment involves stopping vitamin D, hydrating, and managing hypercalcemia.
Pregnancy & Lactation
Safe to use during pregnancy and lactation if vitamin D deficiency is diagnosed, but doses should be monitored to avoid excessive intake.
Side Effects
Contraindications
- Hypercalcemia
- Hypervitaminosis D
- Severe renal impairment
Drug Interactions
Thiazide diuretics
May increase the risk of hypercalcemia.
Phenytoin, Barbiturates
May accelerate the metabolism of vitamin D, reducing its effects.
Bile acid sequestrants (e.g., Cholestyramine)
May impair the absorption of vitamin D.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, weakness, constipation, confusion), kidney damage, and soft tissue calcification. Treatment involves stopping vitamin D, hydrating, and managing hypercalcemia.
Pregnancy & Lactation
Safe to use during pregnancy and lactation if vitamin D deficiency is diagnosed, but doses should be monitored to avoid excessive intake.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved by regulatory authorities
Patent Status
Generic
Clinical Trials
Extensive clinical trials support the efficacy of cholecalciferol in treating and preventing vitamin D deficiency and its associated conditions.
Lab Monitoring
- Serum 25-hydroxyvitamin D levels
- Serum calcium and phosphate levels
- Serum parathyroid hormone (PTH) levels (if indicated)
Doctor Notes
- Advise patients on the importance of regular follow-up for vitamin D and calcium levels.
- Educate patients about the symptoms of hypercalcemia.
Patient Guidelines
- Take exactly as prescribed by your doctor
- Take with food, preferably a main meal
- Do not exceed the recommended dose
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally no effect on ability to drive or operate machinery.
Lifestyle Advice
- Ensure adequate sunlight exposure (while protecting skin)
- Maintain a diet rich in calcium and other essential nutrients
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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