Adults

Oral: 150-450 mg every 6-8 hours. Max 1.8 g/day.

Elderly

No specific dose adjustment is generally required based on age alone, but renal and hepatic function should be monitored.

Renal_impairment

No dosage adjustment needed for mild to moderate renal impairment. For severe impairment, consider lengthening dosing interval.

Onset

Varies by route of administration. Peak plasma concentrations are usually reached within 45-60 minutes after oral administration.

Excretion

Approximately 10-20% excreted in urine and 4-10% in feces as active drug and metabolites. Most is eliminated via bile and feces.

Half life

Approximately 2-3 hours in adults with normal renal and hepatic function.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract (about 90% bioavailability for oral forms). Absorption is not significantly affected by food.

Metabolism

Primarily metabolized in the liver to active and inactive metabolites (e.g., N-demethylclindamycin and clindamycin sulfoxide).

Erythromycin

Antagonistic effect; do not use concurrently.

Kaolin-pectin antidiarrheals

May delay or decrease absorption of clindamycin.

Neuromuscular blocking agents

May enhance the neuromuscular blocking action, leading to increased respiratory depression.