Daprosis
Generic Name
Hypothetical COX-2 Inhibitor
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| daprosis 4 mg tablet | ৳ 150.00 | ৳ 1,050.00 |
Description
Overview of the medicine
Daprosis 4 mg Tablet is a selective cyclooxygenase-2 (COX-2) inhibitor used to relieve pain and inflammation associated with various conditions.
Uses & Indications
Dosage
Adults
Typically 4 mg once daily, or 2 mg twice daily, as directed by a physician. Max 8 mg/day.
Elderly
Initiate with the lowest effective dose; close monitoring for adverse effects is recommended.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe impairment. Not recommended for severe renal failure.
How to Take
Administer orally with or without food. Taking with food may reduce gastrointestinal discomfort.
Mechanism of Action
Selectively inhibits cyclooxygenase-2 (COX-2) enzyme, reducing prostaglandin synthesis, thereby exerting anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Within 30-60 minutes for pain relief.
Excretion
Excreted primarily via urine (approximately 70%) and feces (approximately 30%) as metabolites.
Half life
Approximately 8-12 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, peak plasma concentrations typically reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily via cytochrome P450 enzymes (e.g., CYP2C9).
Side Effects
Contraindications
- Hypersensitivity to the active substance or excipients
- History of asthma, urticaria, or allergic reactions after taking NSAIDs or aspirin
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure, severe hepatic or renal impairment
Drug Interactions
Lithium
May increase lithium plasma levels, leading to toxicity.
Warfarin
May increase the risk of bleeding.
Diuretics
May reduce the natriuretic effect of diuretics.
ACE Inhibitors/ARBs
May diminish the antihypertensive effect and increase the risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management is supportive, including gastric lavage or activated charcoal.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm. Use with caution during first and second trimesters only if clearly needed. Excretion into breast milk is unknown; caution advised.
Side Effects
Contraindications
- Hypersensitivity to the active substance or excipients
- History of asthma, urticaria, or allergic reactions after taking NSAIDs or aspirin
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure, severe hepatic or renal impairment
Drug Interactions
Lithium
May increase lithium plasma levels, leading to toxicity.
Warfarin
May increase the risk of bleeding.
Diuretics
May reduce the natriuretic effect of diuretics.
ACE Inhibitors/ARBs
May diminish the antihypertensive effect and increase the risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management is supportive, including gastric lavage or activated charcoal.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm. Use with caution during first and second trimesters only if clearly needed. Excretion into breast milk is unknown; caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Expired
Clinical Trials
Studies have shown Daprosis 4 mg to be effective in reducing pain and inflammation in patients with osteoarthritis, with a favorable gastrointestinal tolerability profile compared to non-selective NSAIDs.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs)
- Blood pressure monitoring
Doctor Notes
- Advise patients to report any signs of gastrointestinal bleeding or cardiovascular symptoms immediately.
- Consider gastroprotective agents for patients at high risk of GI complications.
Patient Guidelines
- Take exactly as prescribed.
- Do not exceed the recommended dose.
- Report any unusual bleeding or bruising.
- Avoid prolonged exposure to sunlight if skin rash occurs.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's near the time for the next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Patients should be cautious when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid smoking and excessive alcohol.
- Manage stress effectively.
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