Daprosis
Generic Name
Daprosis
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| daprosis 6 mg tablet | ৳ 200.00 | ৳ 1,400.00 |
Description
Overview of the medicine
Daprosis 6 mg Tablet contains Daprosis, a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief and reducing inflammation. It is effective in treating mild to moderate pain conditions such as headaches, muscle aches, dental pain, and menstrual cramps, as well as symptoms of arthritis.
Uses & Indications
Dosage
Adults
One 6 mg tablet every 4-6 hours as needed, not exceeding 24 mg in 24 hours.
Elderly
Start with the lowest effective dose; dosage adjustments may be necessary due to decreased renal function.
Renal_impairment
Use with caution; dose reduction may be required for severe impairment. Consult a doctor.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Daprosis works by inhibiting cyclooxygenase (COX) enzymes, primarily COX-1 and COX-2. This inhibition leads to a reduction in the synthesis of prostaglandins, which are key mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Primarily excreted in urine as metabolites, with a small amount excreted in feces.
Half life
2-3 hours
Absorption
Well absorbed from the gastrointestinal tract, bioavailability of about 90%.
Metabolism
Extensively metabolized in the liver, primarily via cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Daprosis or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Diuretics
Reduced diuretic and antihypertensive effects.
Methotrexate
Increased methotrexate toxicity.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In severe cases, renal failure, hypotension, and respiratory depression may occur. Management involves supportive care and symptomatic treatment. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Use during pregnancy, especially in the third trimester, should be avoided due to potential risks to the fetus. Consult a doctor. Small amounts may pass into breast milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Daprosis or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Diuretics
Reduced diuretic and antihypertensive effects.
Methotrexate
Increased methotrexate toxicity.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In severe cases, renal failure, hypotension, and respiratory depression may occur. Management involves supportive care and symptomatic treatment. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Use during pregnancy, especially in the third trimester, should be avoided due to potential risks to the fetus. Consult a doctor. Small amounts may pass into breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent pending
Clinical Trials
Phase III clinical trials demonstrated significant pain reduction and anti-inflammatory effects with a favorable safety profile.
Lab Monitoring
- Regular monitoring of renal function (creatinine, BUN) for long-term use.
- Liver function tests (ALT, AST) periodically.
- Complete blood count (CBC) to check for anemia.
Doctor Notes
- Assess cardiovascular and gastrointestinal risk factors before prescribing.
- Monitor renal and hepatic function during prolonged therapy.
Patient Guidelines
- Take with food or milk to reduce stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness in some individuals. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid alcohol while taking this medicine.
- Maintain adequate hydration.
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Global Brand Names
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