Deflux
Generic Name
deflux-10-mg-tablet
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deflux 10 mg tablet | ৳ 4.00 | ৳ 60.00 |
Description
Overview of the medicine
Deflux 10 mg Tablet is a medication used to prevent and treat chronic asthma and to relieve symptoms of seasonal and perennial allergic rhinitis. It works by blocking substances in the body called leukotrienes, which cause inflammation and narrowing of the airways.
Uses & Indications
Dosage
Adults
For asthma and allergic rhinitis: 10 mg once daily, in the evening.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is necessary in patients with renal impairment.
How to Take
Take Deflux 10 mg Tablet once daily in the evening, with or without food. It should be taken regularly to be effective, even when you feel well. Do not use for acute asthma attacks.
Mechanism of Action
Deflux (hypothetical generic) is a selective and orally active leukotriene receptor antagonist that specifically binds to the CysLT1 receptor. This binding prevents the action of leukotrienes (LTC4, LTD4, LFE4) which are inflammatory mediators released from various cells (e.g., mast cells, eosinophils) and contribute to bronchoconstriction, mucus secretion, vascular permeability, and eosinophil recruitment in allergic diseases.
Pharmacokinetics
Onset
Within 24 hours for asthma and allergic rhinitis symptom improvement.
Excretion
Primarily excreted in feces via bile (approximately 86%), with minimal renal excretion.
Half life
Approximately 2.7 to 5.5 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations achieved in 2-4 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP3A4, CYP2C9, CYP2A6).
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Acute asthma attacks (not indicated for rescue therapy).
Drug Interactions
Rifampicin
May decrease the plasma concentration of Deflux through induction of hepatic metabolizing enzymes. Monitor clinical response.
Phenobarbital
May decrease the plasma concentration of Deflux due to induction of hepatic metabolizing enzymes.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, the most commonly reported adverse events were abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive. It is not known if Deflux is dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is unknown whether Deflux is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Acute asthma attacks (not indicated for rescue therapy).
Drug Interactions
Rifampicin
May decrease the plasma concentration of Deflux through induction of hepatic metabolizing enzymes. Monitor clinical response.
Phenobarbital
May decrease the plasma concentration of Deflux due to induction of hepatic metabolizing enzymes.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, the most commonly reported adverse events were abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive. It is not known if Deflux is dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is unknown whether Deflux is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of Deflux in the long-term management of asthma and treatment of allergic rhinitis, showing significant improvements in FEV1, reduction in asthma exacerbations, and symptom scores.
Lab Monitoring
- Periodic monitoring of liver function tests may be considered in patients who develop persistent or unexplained symptoms suggestive of hepatic dysfunction.
Doctor Notes
- Counsel patients on the importance of adherence, even when asymptomatic, for optimal asthma control.
- Emphasize that Deflux is not a bronchodilator for acute relief and does not replace inhaled corticosteroids.
- Educate patients about potential neuropsychiatric symptoms and advise them to report any such changes immediately.
Patient Guidelines
- Take Deflux 10 mg Tablet once daily in the evening, as prescribed by your doctor.
- It is not for treating acute asthma attacks; always have your rescue inhaler handy.
- Inform your doctor if you experience any mood changes, agitation, or suicidal thoughts.
- Continue taking the medicine even if you feel well, as it is a preventive medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose to catch up.
Driving Precautions
Deflux may cause dizziness or drowsiness in some individuals. Patients should be cautioned about operating machinery or driving until they are reasonably certain that Deflux does not adversely affect their ability to perform such activities.
Lifestyle Advice
- Avoid known triggers for your asthma and allergic rhinitis.
- Maintain a healthy lifestyle with regular exercise, but consult your doctor about exercise-induced asthma prevention.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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