Administer orally, preferably 30-60 minutes before a meal. Measure the exact dose using the provided dropper. For children aged 1-11 years, weighing <20 kg, the usual dose is 5 mg once daily. For children aged 1-11 years, weighing ≥20 kg, the usual dose is 10 mg once daily. Can be mixed with a small amount of water or fruit juice (apple, orange, pineapple) or soft food (apple sauce, yogurt) for easier administration. Do not chew or crush.

Esomeprazole, an S-isomer of Omeprazole, is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase (proton pump) in the gastric parietal cells. This inhibition prevents the final step of acid production, leading to a profound and long-lasting reduction in gastric acid secretion.

• •Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation
• •Concomitant use with nelfinavir (an antiretroviral drug)

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. After reconstitution, store refrigerated (2-8°C) and use within 28 days. Do not freeze.

Symptoms of overdose are generally mild and self-limiting (e.g., drowsiness, tachycardia, nausea, abdominal pain). No specific antidote is known. Treatment should be symptomatic and supportive. Esomeprazole is extensively protein-bound and not readily dialyzable.

Pregnancy Category B. Studies in animals have not shown harm to the fetus. Limited human data suggest no increased risk. Use during pregnancy only if clearly needed. Esomeprazole is likely excreted in human milk; caution should be exercised when administered to a nursing mother, weighing benefits vs. risks.