Deflux
Generic Name
Montelukast
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deflux 5 mg suspension | ৳ 50.00 | N/A |
Description
Overview of the medicine
Deflux 5 mg Suspension contains Montelukast, a leukotriene receptor antagonist, used for the prophylaxis and chronic treatment of asthma, and for the relief of symptoms of seasonal and perennial allergic rhinitis, particularly in children.
Uses & Indications
Dosage
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
Children_6_14_years
5 mg (one teaspoonful) once daily in the evening.
How to Take
Deflux 5 mg Suspension should be taken orally once daily in the evening. It can be taken with or without food. For asthma, it should be taken in the evening. For allergic rhinitis, the time of administration may be individualized to suit patient needs.
Mechanism of Action
Montelukast selectively blocks the CysLT1 receptor, inhibiting the actions of cysteinyl leukotrienes (LTC4, LTD4, LTE4). These leukotrienes are potent pro-inflammatory eicosanoids that contribute to bronchoconstriction, mucus secretion, vascular permeability, and eosinophil recruitment in allergic diseases and asthma.
Pharmacokinetics
Onset
Clinical improvement generally seen within one day of initiation for asthma and allergic rhinitis.
Excretion
Primarily excreted in the feces via bile (approximately 86%); less than 0.2% is excreted in urine.
Half life
Plasma half-life ranges from approximately 2.7 to 5.5 hours in healthy adults.
Absorption
Rapidly absorbed after oral administration, with mean peak plasma concentration (Cmax) achieved in approximately 2-4 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes CYP2C8, CYP3A4, and CYP2C9. Metabolites are pharmacologically inactive.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation.
- Acute asthma attacks.
Drug Interactions
Rifampicin
May decrease the plasma concentration of Montelukast, requiring careful monitoring.
Gemfibrozil
May increase the plasma concentration of Montelukast, requiring careful monitoring.
Phenobarbital
May decrease the plasma concentration of Montelukast, requiring careful monitoring.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
In cases of overdose, supportive measures should be employed. No specific antidote is known. Montelukast is not significantly removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Deflux should be used during pregnancy only if clearly needed. It is unknown whether Montelukast is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation.
- Acute asthma attacks.
Drug Interactions
Rifampicin
May decrease the plasma concentration of Montelukast, requiring careful monitoring.
Gemfibrozil
May increase the plasma concentration of Montelukast, requiring careful monitoring.
Phenobarbital
May decrease the plasma concentration of Montelukast, requiring careful monitoring.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
In cases of overdose, supportive measures should be employed. No specific antidote is known. Montelukast is not significantly removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Deflux should be used during pregnancy only if clearly needed. It is unknown whether Montelukast is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Montelukast's efficacy and safety in the treatment of asthma and allergic rhinitis across various age groups, including children, establishing its role as a well-tolerated and effective treatment option.
Lab Monitoring
- Routine lab monitoring is not typically required. Liver function tests (LFTs) may be considered if symptoms suggestive of liver dysfunction develop.
Doctor Notes
- Emphasize to patients and caregivers that Montelukast is not for acute asthma attacks.
- Counsel on the potential for neuropsychiatric side effects and advise immediate reporting of any such symptoms.
- Regular follow-up for asthma control and side effect monitoring is crucial.
Patient Guidelines
- This medicine is for prevention and long-term control of asthma, not for immediate relief of acute asthma attacks.
- Continue taking the medicine regularly, even if you feel well and have no symptoms.
- Inform your doctor immediately if you experience any mood changes, agitation, or other neuropsychiatric symptoms.
- Shake the suspension well before use.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Montelukast may cause dizziness or drowsiness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how Deflux affects them.
Lifestyle Advice
- Avoid known allergens that trigger your asthma or allergic rhinitis.
- Maintain a healthy lifestyle, including regular exercise and a balanced diet (as advised by physician).
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