Delfex
Generic Name
Fexofenadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| delfex 180 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Fexofenadine is a non-sedating antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy eyes, and hives.
Uses & Indications
Dosage
Adults
180 mg once daily for seasonal allergic rhinitis or chronic idiopathic urticaria.
Elderly
No specific adjustment usually required, but use with caution.
Renal_impairment
Initial dose 60 mg once daily for patients with renal impairment.
How to Take
Take orally with water, preferably before a meal. Do not take with fruit juice.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist, which means it blocks the action of histamine at H1 receptors, thereby reducing allergic symptoms without significant sedative effects.
Pharmacokinetics
Onset
1 hour
Excretion
Primarily excreted unchanged in feces (80%) and urine (11%).
Half life
Approximately 11-15 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations in 2-3 hours.
Metabolism
Minimally metabolized in the liver (about 5%).
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine or any excipients.
Drug Interactions
Erythromycin or Ketoconazole
May increase plasma levels of fexofenadine.
Antacids (aluminum and magnesium-containing)
Can reduce the absorption of fexofenadine. Separate administration by at least 2 hours.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Hemodialysis does not effectively remove fexofenadine.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine or any excipients.
Drug Interactions
Erythromycin or Ketoconazole
May increase plasma levels of fexofenadine.
Antacids (aluminum and magnesium-containing)
Can reduce the absorption of fexofenadine. Separate administration by at least 2 hours.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Hemodialysis does not effectively remove fexofenadine.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have established the efficacy and safety of fexofenadine for its approved indications. Post-marketing surveillance continues.
Lab Monitoring
- No specific routine lab monitoring is generally required.
Doctor Notes
- Counsel patients to avoid fruit juice consumption around the time of taking fexofenadine due to potential interaction.
- Reassure patients that fexofenadine is a non-sedating antihistamine, though individual responses may vary.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking with fruit juices.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Fexofenadine is generally non-sedating, but individuals should exercise caution until they know how they react to the medication, especially when driving or operating machinery.
Lifestyle Advice
- Avoid known allergens to reduce the frequency of allergic reactions.
- Maintain good hydration.
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