Delfex
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| delfex 30 mg suspension | ৳ 55.00 | N/A |
Description
Overview of the medicine
Delfex 30 mg Suspension is an antihistamine medication containing Fexofenadine Hydrochloride, used to relieve allergy symptoms such as runny nose, sneezing, itchy or watery eyes, and itching of the nose or throat. It is a non-drowsy formulation suitable for children and adults.
Uses & Indications
Dosage
Adults
This 30 mg/5 mL suspension is primarily intended for pediatric use. Adults generally use higher strength tablets (e.g., 60 mg or 180 mg). For pediatric dosage: Children 6-11 years: 5 mL (30 mg) twice daily. Children 2-5 years: 2.5 mL (15 mg) twice daily.
Elderly
No specific dose adjustment for elderly with normal renal function. Consult a physician for renal impairment.
Renal_impairment
For children 6-11 years with impaired renal function, the initial dose is 30 mg once daily. For children 2-5 years with impaired renal function, the initial dose is 15 mg once daily. Consult a physician.
How to Take
Take orally, with or without food. Shake the suspension well before each use. Use a measuring device for accurate dosing. Avoid taking with fruit juice.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It blocks the action of histamine, a natural substance in the body that causes allergic symptoms. By blocking H1-receptors, it prevents the effects of histamine on capillaries and smooth muscles, reducing allergic reactions without significant central nervous system effects (thus, non-sedating).
Pharmacokinetics
Onset
Within 1 hour
Excretion
Approximately 80% excreted in feces and 11% in urine, largely as unchanged drug.
Half life
Approximately 14.4 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in 1-3 hours.
Metabolism
Minimally metabolized (approximately 5% of total dose). Primarily hepatic.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation
Drug Interactions
Erythromycin, Ketoconazole
May increase fexofenadine plasma concentrations (though generally not clinically significant).
Antacids (containing aluminum or magnesium)
May decrease fexofenadine absorption. Separate administration by about 2 hours.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Treatment is supportive and symptomatic; hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Fexofenadine is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation
Drug Interactions
Erythromycin, Ketoconazole
May increase fexofenadine plasma concentrations (though generally not clinically significant).
Antacids (containing aluminum or magnesium)
May decrease fexofenadine absorption. Separate administration by about 2 hours.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Treatment is supportive and symptomatic; hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Fexofenadine is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date, or as specified on packaging.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved by FDA (USA) and DGDA (Bangladesh)
Patent Status
Generic available, original patent expired
Clinical Trials
Extensive clinical trials have demonstrated fexofenadine's efficacy and safety in treating seasonal allergic rhinitis and chronic idiopathic urticaria across various age groups, showing low incidence of sedation compared to older antihistamines.
Lab Monitoring
- Generally, no routine laboratory monitoring is required. Renal function may be monitored in patients with pre-existing renal impairment.
Doctor Notes
- Advise patients to shake the suspension well before each use and use an accurate measuring device.
- Emphasize avoiding fruit juices due to potential interaction.
- Confirm patient understands the difference between sedating and non-sedating antihistamines.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking with fruit juices.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Fexofenadine is generally non-drowsy. However, individuals should assess their response before driving or operating machinery, especially when starting treatment.
Lifestyle Advice
- Avoid known allergens to reduce symptoms.
- Maintain good hydration.
- Get adequate rest.
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Global Brand Names
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