Derma Aid
Generic Name
Clobetasol Propionate + Gentamicin + Miconazole Nitrate
Manufacturer
Radiant Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| derma aid 5 mg powder | ৳ 20.00 | N/A |
| derma aid 5 mg ointment | ৳ 24.00 | N/A |
Description
Overview of the medicine
Derma Aid cream is a combination medication used to treat a variety of skin conditions that involve inflammation, itching, and secondary bacterial or fungal infections. It contains a potent corticosteroid (Clobetasol Propionate) to reduce inflammation and itching, an antibiotic (Gentamicin) to fight bacterial infections, and an antifungal (Miconazole Nitrate) to combat fungal infections.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area once or twice daily, or as directed by the physician. Treatment should not exceed 2-4 weeks without reassessment.
Elderly
No specific dose adjustment required, but caution is advised due to potential for thinner skin and increased absorption.
Renal_impairment
No specific dose adjustment for topical use; systemic absorption is minimal.
How to Take
For external use only. Apply thinly and gently rub into the affected area. Wash hands before and after application. Avoid contact with eyes, nose, and mouth.
Mechanism of Action
Clobetasol Propionate is a potent corticosteroid that suppresses the inflammatory response through multiple mechanisms including vasoconstriction, decrease in collagen synthesis, and stabilization of lysosomal membranes. Gentamicin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by irreversibly binding to the 30S ribosomal subunit. Miconazole Nitrate is an azole antifungal that inhibits the biosynthesis of ergosterol, a vital component of fungal cell membranes, leading to increased membrane permeability and leakage of cellular contents.
Pharmacokinetics
Onset
Relief from symptoms typically within a few days of starting treatment.
Excretion
Systemically absorbed Clobetasol is excreted via the kidneys and bile. Gentamicin is primarily excreted unchanged by the kidneys. Miconazole's systemic excretion is minimal.
Half life
Not well-defined for topical application due to minimal systemic absorption.
Absorption
Minimal systemic absorption through intact skin. Absorption may increase with occlusion, inflammation, or on areas with thin skin. Gentamicin and Miconazole also show minimal systemic absorption.
Metabolism
Systemically absorbed Clobetasol is metabolized primarily in the liver. Gentamicin and Miconazole have limited systemic metabolism.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate, Gentamicin, Miconazole, or any excipients.
- Viral skin infections (e.g., herpes simplex, varicella).
- Tuberculosis of the skin, acne vulgaris, rosacea, perioral dermatitis.
- Not for use on children under 1 year of age.
- Not for prolonged use on large areas or under occlusive dressings without medical supervision.
Drug Interactions
0
No significant systemic drug interactions are expected due to minimal topical absorption.
1
Avoid concomitant use of other topical steroids unless advised by a physician to prevent cumulative steroid effects.
Storage
Store in a cool and dry place (below 30°C), away from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Prolonged or excessive use may lead to local adverse effects (skin thinning, striae) and potential systemic corticosteroid effects (e.g., Cushing's syndrome, HPA axis suppression) if significant absorption occurs. Management involves gradual withdrawal of the drug and symptomatic treatment.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor. Prolonged or extensive use should be avoided.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate, Gentamicin, Miconazole, or any excipients.
- Viral skin infections (e.g., herpes simplex, varicella).
- Tuberculosis of the skin, acne vulgaris, rosacea, perioral dermatitis.
- Not for use on children under 1 year of age.
- Not for prolonged use on large areas or under occlusive dressings without medical supervision.
Drug Interactions
0
No significant systemic drug interactions are expected due to minimal topical absorption.
1
Avoid concomitant use of other topical steroids unless advised by a physician to prevent cumulative steroid effects.
Storage
Store in a cool and dry place (below 30°C), away from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Prolonged or excessive use may lead to local adverse effects (skin thinning, striae) and potential systemic corticosteroid effects (e.g., Cushing's syndrome, HPA axis suppression) if significant absorption occurs. Management involves gradual withdrawal of the drug and symptomatic treatment.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor. Prolonged or extensive use should be avoided.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date (check package for specific expiry).
Availability
Available in all registered pharmacies in Bangladesh
Approval Status
DGDA approved
Patent Status
Off-patent (generic available)
Clinical Trials
Specific clinical trials for this fixed-dose combination are often conducted for local regulatory approval, but extensive global trials for common topical combinations are less common than for new systemic drugs. Efficacy is supported by individual component trials.
Doctor Notes
- Emphasize short-term use (max 2-4 weeks) due to potent steroid.
- Advise against use on face, groin, or axillae unless specifically indicated and under close supervision.
- Educate patients on signs of skin atrophy or systemic effects.
- Not for primary treatment of fungal or bacterial infections; suitable for complicated inflammatory conditions.
Patient Guidelines
- Use only as directed by your doctor.
- For external use only; do not swallow.
- Avoid contact with eyes, nose, mouth, and other mucous membranes.
- Do not apply to open wounds, broken skin, or extensive areas of the body.
- Wash hands thoroughly after applying the cream.
- Do not use for longer than the prescribed duration, especially on the face or in skin folds.
- Inform your doctor if your condition does not improve or worsens.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Derma Aid cream is for topical use and is not expected to affect the ability to drive or operate machinery.
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