Dextropac
Generic Name
Dextrose Monohydrate
Manufacturer
ABC Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dextropac 25 injection | ৳ 48.14 | N/A |
Description
Overview of the medicine
Dextropac-25-Injection contains Dextrose Monohydrate (Glucose) 25% w/v. It is an intravenous solution primarily used to replenish fluid and carbohydrate in patients, providing a source of energy and treating hypoglycemia, insulin shock, and dehydration. It is hypertonic.
Uses & Indications
Dosage
Adults
Dosage varies widely based on patient's metabolic needs, fluid balance, and glucose levels. Typically, 20-50 mL of 25% Dextrose is given slowly intravenously, or infused as part of a total parenteral nutrition (TPN) regimen. The rate of infusion should not exceed 0.5 g/kg/hour.
Elderly
Similar to adult dosage, but close monitoring for fluid overload and electrolyte imbalances is crucial due to potential renal and cardiac impairment.
Renal_impairment
Use with caution. Dosage may need to be adjusted based on fluid status and electrolyte balance. Close monitoring of serum glucose and electrolytes is essential.
How to Take
Administer intravenously, usually through a peripheral or central vein. For 25% Dextrose, slow administration is crucial to avoid osmotic changes and local irritation. Rapid infusion should be avoided.
Mechanism of Action
Dextrose is a monosaccharide, readily metabolized by the body to produce energy. It provides calories and helps maintain fluid and electrolyte balance, especially when oral intake is restricted. It raises blood glucose levels.
Pharmacokinetics
Onset
Immediate.
Excretion
Carbon dioxide is excreted via the lungs, and water is excreted via the kidneys.
Half life
Rapidly metabolized; not applicable in a traditional sense.
Absorption
Immediately available systemically upon intravenous administration.
Metabolism
Oxidized to carbon dioxide and water, stored as glycogen in liver and muscle.
Side Effects
Contraindications
- •Known allergy to corn or corn products
- •Hyperglycemia (high blood sugar)
- •Diabetic coma (unless confirmed hypoglycemic)
- •Anuria (absence of urine formation)
- •Intracranial or intraspinal hemorrhage
Drug Interactions
Insulin
Insulin will counteract the glucose-raising effect of Dextrose. Dosage adjustments may be needed.
Corticosteroids
Corticosteroids can increase blood glucose levels, potentially requiring higher Dextrose doses or careful monitoring.
Diuretics (e.g., Thiazides)
Some diuretics can affect glucose metabolism, potentially altering the patient's response to Dextrose.
Storage
Store at controlled room temperature (20°C to 25°C). Do not freeze. Protect from light.
Overdose
Symptoms of overdose include severe hyperglycemia, glycosuria, osmotic diuresis leading to dehydration, and electrolyte imbalances (e.g., hypokalemia, hypophosphatemia). Treatment involves discontinuing Dextrose, administering insulin if necessary, and correcting fluid and electrolyte imbalances.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy; closely monitor maternal and fetal glucose levels. Generally considered safe during lactation when indicated, but consult a healthcare professional.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, depending on manufacturer.
Availability
Hospitals, retail pharmacies
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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