Dextrose
Generic Name
Dextrose 10% Injection
Manufacturer
Various
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dextrose 10 injection | ৳ 77.96 | N/A |
Description
Overview of the medicine
Dextrose 10% Injection is a sterile, nonpyrogenic solution of Dextrose (D-glucose) in water for intravenous administration. It is a source of calories and water for hydration, used to treat hypoglycemia, insulin shock, and to restore blood glucose levels.
Uses & Indications
Dosage
Adults
Dosage is individualized based on patient's age, weight, clinical condition, and fluid and glucose requirements. Typically, 250-1000 mL infused intravenously at a rate determined by the physician.
Elderly
Similar to adults, but with close monitoring for fluid and electrolyte balance due to potential renal or cardiac impairment.
Renal_impairment
Administer with caution and monitor fluid and electrolyte balance closely. Dosage adjustments may be necessary to avoid fluid overload.
How to Take
Administered intravenously, usually through a peripheral or central vein. The rate of infusion should be carefully controlled to avoid hyperglycemia and osmotic diuresis.
Mechanism of Action
Dextrose is a monosaccharide readily metabolized by the body. It provides calories, helps maintain fluid balance, and acts as a readily available source of energy by being converted into carbon dioxide and water, releasing energy in the process.
Pharmacokinetics
Onset
Rapid, within minutes of administration.
Excretion
Metabolic end products (CO2 and water) are excreted via the lungs and kidneys, respectively.
Half life
Not applicable in the traditional sense as it is rapidly metabolized. Its glucose-raising effect is transient.
Absorption
Administered intravenously, hence 100% bioavailability directly into the systemic circulation.
Metabolism
Metabolized to carbon dioxide and water through the Kreb's cycle, releasing energy.
Side Effects
Contraindications
- Known allergy to corn or corn products (dextrose is derived from corn)
- Anuria (absence of urine production)
- Uncontrolled diabetes mellitus (unless to treat severe hypoglycemia)
- Intracranial or intraspinal hemorrhage (due to potential for increased intracranial pressure)
- Delirium tremens (in dehydrated patients)
Drug Interactions
Corticosteroids
Corticosteroids may increase blood glucose levels, potentially requiring higher doses of dextrose or closer monitoring.
Insulin and Oral Hypoglycemic Agents
Dextrose administration may necessitate adjustment of insulin or oral hypoglycemic agent dosage due to its hyperglycemic effect.
Storage
Store at room temperature (20-25°C or 68-77°F). Avoid excessive heat and freezing. Do not store partially used containers.
Overdose
Overdose may lead to hyperglycemia, glycosuria, osmotic diuresis, fluid and electrolyte disturbances (e.g., hyponatremia, hypokalemia), and dehydration. Treatment involves discontinuing the infusion, administering insulin if hyperglycemia is severe, and correcting fluid and electrolyte imbalances.
Pregnancy & Lactation
Generally considered safe during pregnancy and lactation, as dextrose is a natural body constituent. However, blood glucose levels should be closely monitored in both mother and infant.
Side Effects
Contraindications
- Known allergy to corn or corn products (dextrose is derived from corn)
- Anuria (absence of urine production)
- Uncontrolled diabetes mellitus (unless to treat severe hypoglycemia)
- Intracranial or intraspinal hemorrhage (due to potential for increased intracranial pressure)
- Delirium tremens (in dehydrated patients)
Drug Interactions
Corticosteroids
Corticosteroids may increase blood glucose levels, potentially requiring higher doses of dextrose or closer monitoring.
Insulin and Oral Hypoglycemic Agents
Dextrose administration may necessitate adjustment of insulin or oral hypoglycemic agent dosage due to its hyperglycemic effect.
Storage
Store at room temperature (20-25°C or 68-77°F). Avoid excessive heat and freezing. Do not store partially used containers.
Overdose
Overdose may lead to hyperglycemia, glycosuria, osmotic diuresis, fluid and electrolyte disturbances (e.g., hyponatremia, hypokalemia), and dehydration. Treatment involves discontinuing the infusion, administering insulin if hyperglycemia is severe, and correcting fluid and electrolyte imbalances.
Pregnancy & Lactation
Generally considered safe during pregnancy and lactation, as dextrose is a natural body constituent. However, blood glucose levels should be closely monitored in both mother and infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture when stored under recommended conditions.
Availability
Widely available in hospitals, clinics, and pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Due to its long-standing and fundamental role in medicine, extensive clinical trials for Dextrose 10% as a standalone solution are typically not ongoing for basic efficacy. Research often focuses on optimal administration protocols, specific patient populations, or use in combination with other therapies.
Lab Monitoring
- Blood glucose levels
- Serum electrolytes (sodium, potassium, chloride, bicarbonate)
- Renal function (BUN, creatinine)
- Fluid balance (input/output)
Doctor Notes
- Monitor blood glucose, electrolytes, and fluid balance regularly.
- Adjust infusion rate based on patient's metabolic needs and glucose tolerance.
- Use cautiously in patients with diabetes, cardiac, or renal insufficiency.
Patient Guidelines
- This medication is administered by a healthcare professional.
- Report any discomfort or adverse reactions experienced during or after the infusion.
- Inform your doctor about any history of diabetes, heart, or kidney problems.
Missed Dose Advice
Not applicable for a continuously administered or acutely prescribed intravenous solution. Administration is typically managed by healthcare professionals in a clinical setting.
Driving Precautions
No direct precautions related to driving, as this medication is administered in a clinical setting and does not typically impair driving ability. However, underlying medical conditions or adverse effects might.
Lifestyle Advice
- Maintain a balanced diet as advised by your healthcare provider once oral intake is resumed.
- Stay hydrated by drinking adequate fluids unless restricted by a medical condition.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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