Dialon
Generic Name
Gliclazide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dialon 1 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Dialon 1 mg Tablet is an oral anti-diabetic medication containing Gliclazide, used to manage blood sugar levels in adults with type 2 diabetes mellitus. It belongs to the sulfonylurea class of drugs, primarily working to stimulate insulin release from the pancreas.
Uses & Indications
Dosage
Adults
For Gliclazide, typical doses range from 40 mg to 320 mg daily for immediate release, or 30 mg to 120 mg daily for modified release. For Dialon 1 mg Tablet, the specific dosage should be determined by a physician based on the patient's condition and blood glucose levels. Usually taken once daily with breakfast.
Elderly
Lower initial doses and careful titration are recommended due to increased risk of hypoglycemia. Renal function should be monitored.
Renal_impairment
No specific dose adjustment for mild to moderate renal impairment, but caution is advised. Avoid in severe impairment.
How to Take
Oral, taken with food, preferably breakfast.
Mechanism of Action
Gliclazide works by stimulating the beta cells in the pancreas to release more insulin. It also increases peripheral sensitivity to insulin and reduces hepatic glucose production.
Pharmacokinetics
Onset
Hypoglycemic effect usually begins within 1 hour.
Excretion
Primarily excreted in the urine (60-70%) as metabolites, with a small amount excreted in feces.
Half life
The plasma half-life is approximately 8 to 20 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations reached within 2-6 hours.
Metabolism
Extensively metabolized in the liver by CYP2C9, primarily to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Gliclazide or other sulfonylureas
- Type 1 diabetes mellitus
- Diabetic ketoacidosis
- Severe renal or hepatic impairment
- Pregnancy and lactation
Drug Interactions
Fluconazole
Increases hypoglycemic effect of Gliclazide.
Beta-blockers
May mask symptoms of hypoglycemia.
ACE Inhibitors
May enhance glucose-lowering effect.
Corticosteroids
May reduce the hypoglycemic effect.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms include severe hypoglycemia (sweating, tremor, confusion, drowsiness, coma). Management involves immediate administration of oral glucose, intravenous glucose if severe, and close monitoring.
Pregnancy & Lactation
Gliclazide is contraindicated during pregnancy and lactation. Insulin is the preferred treatment for glycemic control in pregnant women with diabetes.
Side Effects
Contraindications
- Hypersensitivity to Gliclazide or other sulfonylureas
- Type 1 diabetes mellitus
- Diabetic ketoacidosis
- Severe renal or hepatic impairment
- Pregnancy and lactation
Drug Interactions
Fluconazole
Increases hypoglycemic effect of Gliclazide.
Beta-blockers
May mask symptoms of hypoglycemia.
ACE Inhibitors
May enhance glucose-lowering effect.
Corticosteroids
May reduce the hypoglycemic effect.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms include severe hypoglycemia (sweating, tremor, confusion, drowsiness, coma). Management involves immediate administration of oral glucose, intravenous glucose if severe, and close monitoring.
Pregnancy & Lactation
Gliclazide is contraindicated during pregnancy and lactation. Insulin is the preferred treatment for glycemic control in pregnant women with diabetes.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date.
Availability
Pharmacies worldwide
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Gliclazide in managing type 2 diabetes. Ongoing and completed trials continue to explore its use in various populations and combinations, including cardiovascular outcomes.
Lab Monitoring
- Regular blood glucose monitoring
- HbA1c levels (every 3-6 months)
- Renal function tests (e.g., serum creatinine, eGFR)
- Liver function tests
Doctor Notes
- Emphasize comprehensive patient education regarding hypoglycemia recognition, prevention, and management strategies.
- Regularly assess renal and hepatic function, especially in elderly patients, to minimize accumulation and adverse effects.
- Consider Gliclazide's cardiovascular neutrality compared to some other sulfonylureas when selecting therapy.
Patient Guidelines
- Adhere strictly to the prescribed diet and exercise regimen.
- Monitor blood glucose levels regularly as advised by your doctor.
- Be aware of the symptoms of hypoglycemia (e.g., sweating, trembling, confusion) and always carry a source of sugar (e.g., glucose tablets, fruit juice).
- Do not skip meals while on this medication.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it's almost time for the next dose. Do not double the dose to compensate for a missed one.
Driving Precautions
Patients should be aware of the risk of hypoglycemia and its potential impact on driving ability. If you experience symptoms of hypoglycemia, do not drive or operate machinery.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Engage in regular physical activity as appropriate.
- Avoid excessive alcohol consumption.
- Manage stress through relaxation techniques.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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