Dialon
Generic Name
Glimepiride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dialon 2 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Dialon 2 mg tablet contains Glimepiride, an oral antidiabetic drug from the sulfonylurea class, used to lower blood glucose levels in adults with type 2 diabetes mellitus. It helps the pancreas release more insulin.
Uses & Indications
Dosage
Adults
Initial dose is 1-2 mg once daily, administered with breakfast or the first main meal. Dosage can be titrated up to a maximum of 8 mg once daily based on blood glucose response.
Elderly
Start with a low initial dose of 1 mg once daily and titrate carefully to minimize the risk of hypoglycemia. Monitor renal function.
Renal_impairment
Initial dose should be 1 mg once daily. Dose titration should be based on blood glucose levels and renal function. Avoid in severe renal impairment.
How to Take
Take orally once daily, usually with breakfast or the first main meal of the day. Swallow the tablet whole with water; do not crush, chew, or divide.
Mechanism of Action
Glimepiride primarily acts by stimulating the beta cells of the pancreas to release insulin. It also enhances the sensitivity of peripheral tissues to insulin, leading to increased glucose uptake and utilization.
Pharmacokinetics
Onset
Within 2-3 hours
Excretion
Approximately 60% of a dose is excreted in the urine and 40% in the feces as metabolites.
Half life
5-9 hours (average 7 hours)
Absorption
Rapid and complete absorption after oral administration; bioavailability is 100%. Peak plasma concentrations are reached in 2-3 hours.
Metabolism
Completely metabolized in the liver by CYP2C9 to two main inactive metabolites (a hydroxy metabolite and a carboxy metabolite).
Side Effects
Contraindications
- Known hypersensitivity to glimepiride or other sulfonylureas or sulfonamides.
- Type 1 diabetes mellitus.
- Diabetic ketoacidosis, with or without coma.
- Severe renal or hepatic impairment.
- Pregnancy and lactation.
Drug Interactions
Decreased Hypoglycemic Effect
Co-administration with corticosteroids, diuretics (thiazides), thyroid hormones, estrogens, oral contraceptives, phenothiazines, barbiturates, rifampicin, adrenaline and sympathomimetics, glucagon, high dose nicotinic acid, laxatives (chronic use), phenytoin, diazoxide.
Increased Hypoglycemic Effect
Co-administration with insulin, metformin, NSAIDs, salicylates, sulfonamides, fibrates, fluoxetine, ACE inhibitors, beta-blockers, chloramphenicol, coumarin derivatives, MAO inhibitors, probenecid, sympatholytics, tetracyclines, tritoqualine, cyclophosphamide, disopyramide, fenfluramine, miconazole, pentoxifylline (parenteral high dose), phenylbutazone, azapropazone, oxyphenbutazone, quinolones.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of glimepiride can lead to hypoglycemia, which may range from mild to severe, potentially causing coma, seizures, or other neurological impairment. Management involves immediate administration of glucose (oral for conscious patients, intravenous for unconscious patients) and monitoring blood glucose levels for at least 24-48 hours.
Pregnancy & Lactation
Glimepiride is contraindicated during pregnancy due to potential fetal harm (hypoglycemia). It is also contraindicated during lactation as it may be excreted in breast milk and cause hypoglycemia in the infant.
Side Effects
Contraindications
- Known hypersensitivity to glimepiride or other sulfonylureas or sulfonamides.
- Type 1 diabetes mellitus.
- Diabetic ketoacidosis, with or without coma.
- Severe renal or hepatic impairment.
- Pregnancy and lactation.
Drug Interactions
Decreased Hypoglycemic Effect
Co-administration with corticosteroids, diuretics (thiazides), thyroid hormones, estrogens, oral contraceptives, phenothiazines, barbiturates, rifampicin, adrenaline and sympathomimetics, glucagon, high dose nicotinic acid, laxatives (chronic use), phenytoin, diazoxide.
Increased Hypoglycemic Effect
Co-administration with insulin, metformin, NSAIDs, salicylates, sulfonamides, fibrates, fluoxetine, ACE inhibitors, beta-blockers, chloramphenicol, coumarin derivatives, MAO inhibitors, probenecid, sympatholytics, tetracyclines, tritoqualine, cyclophosphamide, disopyramide, fenfluramine, miconazole, pentoxifylline (parenteral high dose), phenylbutazone, azapropazone, oxyphenbutazone, quinolones.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of glimepiride can lead to hypoglycemia, which may range from mild to severe, potentially causing coma, seizures, or other neurological impairment. Management involves immediate administration of glucose (oral for conscious patients, intravenous for unconscious patients) and monitoring blood glucose levels for at least 24-48 hours.
Pregnancy & Lactation
Glimepiride is contraindicated during pregnancy due to potential fetal harm (hypoglycemia). It is also contraindicated during lactation as it may be excreted in breast milk and cause hypoglycemia in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies nationwide
Approval Status
Approved by FDA and local regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Glimepiride has undergone extensive clinical trials demonstrating its efficacy and safety in managing type 2 diabetes, both as monotherapy and in combination with other antidiabetic agents. Ongoing research explores its long-term cardiovascular outcomes and comparisons with newer agents.
Lab Monitoring
- Regular monitoring of blood glucose levels (fasting and post-prandial).
- HbA1c levels every 3-6 months to assess long-term glycemic control.
- Renal function tests (creatinine, GFR) periodically.
- Liver function tests (ALT, AST) periodically.
Doctor Notes
- Emphasize patient education on hypoglycemia recognition and management.
- Stress the importance of diet and exercise adherence as fundamental to diabetes management.
- Monitor renal and hepatic function, especially in elderly and high-risk patients.
- Be cautious when combining with other drugs that can affect blood glucose levels.
Patient Guidelines
- Take Dialon exactly as prescribed by your doctor and do not change the dose without consultation.
- Do not skip meals and maintain a regular eating schedule to prevent hypoglycemia.
- Learn to recognize the symptoms of hypoglycemia (e.g., sweating, trembling, dizziness, hunger) and how to manage it (e.g., consuming a quick source of sugar).
- Regularly monitor your blood glucose levels as advised by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Patients should be aware of the symptoms of hypoglycemia, which can impair their ability to concentrate and react, thereby affecting their ability to drive or operate machinery. If hypoglycemia occurs, avoid driving or operating heavy machinery.
Lifestyle Advice
- Adhere to a balanced diet plan recommended by your healthcare provider.
- Engage in regular physical activity suitable for your condition.
- Maintain a healthy body weight.
- Limit alcohol consumption.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Dialon Brand
Other medicines available under the same brand name
