Medicine Information

Dinafex

Name: Dinafex
Brand: Dinafex
Rating: 4.5 (117 reviews)

Tablet120 mgAntihistamineATC: R06AX26

Generic Name

Fexofenadine Hydrochloride

Manufacturer

Reputable Pharmaceutical Company

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dinafex 120 mg tablet	৳ 9.00	৳ 90.00

Description

Overview of the medicine

Dinafex 120 mg Tablet is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, and hives. It belongs to a class of medications called H1 antagonists.

Uses & Indications

Seasonal Allergic Rhinitis

Chronic Idiopathic Urticaria

Dosage

Adults

120 mg or 180 mg once daily.

Elderly

No dosage adjustment generally required for elderly patients with normal renal function.

Renal_impairment

60 mg once daily for patients with impaired renal function (creatinine clearance < 80 mL/min).

How to Take

Take orally with water. Can be taken with or without food. Avoid taking with fruit juice.

Mechanism of Action

Fexofenadine, a peripheral H1-receptor antagonist, selectively blocks histamine H1 receptors. It does not readily cross the blood-brain barrier, resulting in a low incidence of sedation.

Pharmacokinetics

Onset

Within 1 hour

Excretion

Primarily excreted unchanged in feces (80%) and urine (11%).

Half life

Approximately 14 hours

Absorption

Rapidly absorbed after oral administration. Peak plasma concentrations are reached in 1-3 hours.

Metabolism

Minimally metabolized (less than 5%) in the liver.

Side Effects

Contraindications

Hypersensitivity to fexofenadine or any component of the formulation.

Drug Interactions

Erythromycin or Ketoconazole

May increase fexofenadine plasma concentrations (due to inhibition of P-glycoprotein), though not consistently associated with increased adverse effects.

Antacids containing aluminum and magnesium

May decrease absorption of fexofenadine. Separate administration by approximately 2 hours.

Storage

Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms may include drowsiness, dizziness, and dry mouth. Management is symptomatic and supportive; consider activated charcoal if recent ingestion.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Caution is advised during breastfeeding as fexofenadine is excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per box30 tablets per box

Shelf Life

24 months

Availability

Pharmacies, hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Generic available

Clinical Trials

Extensively studied in clinical trials demonstrating efficacy and safety for allergic rhinitis and chronic idiopathic urticaria.

Lab Monitoring

No routine lab monitoring required. May monitor renal function in patients with renal impairment.

Doctor Notes

Counsel patients to avoid concomitant administration with fruit juices.
Fexofenadine is a non-sedating antihistamine, making it suitable for patients requiring alertness.
Adjust dose in renal impairment.

Patient Guidelines

Do not exceed the recommended dose.
Avoid taking with fruit juices.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.

Driving Precautions

Generally considered non-sedating, but individual response may vary. Exercise caution until you know how the medicine affects you, especially if you experience dizziness or drowsiness.