Dinafex
Generic Name
Desloratadine
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dinafex 30 mg suspension | ৳ 55.00 | N/A |
Description
Overview of the medicine
Dinafex 30 mg Suspension is an antihistamine medication containing Desloratadine, typically formulated as 2.5 mg/5 mL, with '30 mg' referring to the total Desloratadine content in a standard pack size (e.g., 60 mL bottle). It is used for relieving symptoms associated with seasonal allergic rhinitis and chronic idiopathic urticaria. It provides non-drowsy relief from sneezing, runny nose, itchy or watery eyes, and itching.
Uses & Indications
Dosage
Adults
Adults and adolescents 12 years of age and over: 5 mg (10 mL) once daily.
Elderly
No specific dosage adjustment is recommended, but caution is advised due to potential age-related decrease in renal or hepatic function.
Renal_impairment
For patients with renal impairment, a starting dose of 2.5 mg (5 mL) every other day is recommended.
How to Take
Dinafex Suspension should be taken orally, with or without food. Shake the bottle well before each use. Use a calibrated measuring spoon or cup for accurate dosing.
Mechanism of Action
Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor antagonist activity. It prevents histamine from binding to H1 receptors, thereby inhibiting the symptoms caused by histamine release, such as itching, sneezing, and vasodilation.
Pharmacokinetics
Onset
Within 1-3 hours
Excretion
Primarily excreted via urine and feces as metabolites.
Half life
Approximately 27 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached approximately 3 hours after administration.
Metabolism
Extensively metabolized in the liver to 3-hydroxydesloratadine (an active metabolite) and other conjugates via cytochrome P450 enzymes.
Side Effects
Contraindications
- •Hypersensitivity to Desloratadine, Loratadine, or any component of the formulation
- •Severe hepatic impairment (use with caution)
Drug Interactions
Cimetidine
May increase desloratadine plasma levels.
Fluoxetine
May increase desloratadine plasma levels.
Azithromycin
May increase desloratadine plasma levels.
Erythromycin
May increase desloratadine plasma levels.
Ketoconazole
May increase desloratadine plasma levels.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. In case of overdose, symptomatic and supportive treatment is recommended. Desloratadine is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Desloratadine passes into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA (USA) and DGDA (Bangladesh)
Patent Status
Generic available (Original patent expired)
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Global Brand Names
International brand names for this medicine
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