Dofixim
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dofixim 100 mg capsule | ৳ 21.00 | ৳ 84.00 |
Description
Overview of the medicine
Cefixime is a broad-spectrum cephalosporin antibiotic used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
The usual adult dose is 200 mg to 400 mg daily. This can be given as a single daily dose or in two divided doses (e.g., 100 mg every 12 hours). For 100mg capsules, typically 1-2 capsules every 12 hours.
Elderly
No specific dose adjustment is required for elderly patients with normal renal function.
Renal_impairment
Dose adjustment is recommended for patients with creatinine clearance less than 60 mL/min. For CrCl 21-60 mL/min, 75% of the standard dose; for CrCl < 20 mL/min, 50% of the standard dose.
How to Take
Can be taken with or without food. To minimize gastrointestinal upset, it may be taken with food.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid onset of action.
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. No significant biliary or fecal excretion.
Half life
3-4 hours.
Absorption
Approximately 40-50% orally absorbed, absorption is slightly delayed by food but not significantly affected.
Metabolism
Minimal metabolism occurs.
Side Effects
Contraindications
- Hypersensitivity to Cefixime, other cephalosporins, or penicillins.
- Patients with a history of severe allergic reactions to beta-lactam antibiotics.
Drug Interactions
Carbamazepine
May increase plasma carbamazepine levels when co-administered.
Oral Anticoagulants (e.g., Warfarin)
May increase prothrombin time (INR), requiring close monitoring and dose adjustment of anticoagulants.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Supportive therapy should be instituted as necessary.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed. Caution should be exercised when administered to a nursing mother, as Cefixime may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Cefixime, other cephalosporins, or penicillins.
- Patients with a history of severe allergic reactions to beta-lactam antibiotics.
Drug Interactions
Carbamazepine
May increase plasma carbamazepine levels when co-administered.
Oral Anticoagulants (e.g., Warfarin)
May increase prothrombin time (INR), requiring close monitoring and dose adjustment of anticoagulants.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Supportive therapy should be instituted as necessary.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed. Caution should be exercised when administered to a nursing mother, as Cefixime may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
FDA approved, DGDA approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Cefixime in various bacterial infections across different patient populations.
Lab Monitoring
- Monitor renal function in patients with pre-existing renal impairment.
- Monitor prothrombin time/INR in patients receiving concomitant oral anticoagulants.
Doctor Notes
- Prescribe based on local susceptibility patterns.
- Monitor for signs of hypersensitivity reactions, including anaphylaxis.
- Advise patients on completing the full course to minimize resistance development.
Patient Guidelines
- Complete the full course of medication as prescribed, even if symptoms improve.
- Do not share this medication with others, even if they have similar symptoms.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.
Driving Precautions
Cefixime generally has no or negligible influence on the ability to drive and use machines. However, if side effects like dizziness occur, patients should avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
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