Doxolator
Generic Name
Doxolator 200 mg Tablet
Manufacturer
PharmaCorp Innovations Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| doxolator 200 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Doxolator 200 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It works by blocking certain natural substances in the body that cause inflammation and pain.
Uses & Indications
Dosage
Adults
The usual recommended dose is 200 mg taken orally 2-3 times daily, preferably with food. Do not exceed 600 mg in 24 hours.
Elderly
Lower doses may be required due to increased sensitivity and potential for renal impairment. Start with 200 mg once or twice daily.
Renal_impairment
Use with caution. Dosage reduction may be necessary in patients with mild to moderate renal impairment. Avoid in severe renal impairment.
How to Take
Take Doxolator 200 mg Tablet orally, preferably with food or milk, to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
Mechanism of Action
Doxolator exerts its anti-inflammatory, analgesic, and antipyretic effects primarily through the inhibition of cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2. This inhibition leads to a reduced synthesis of prostaglandins, which are key mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Analgesic effect: 30-60 minutes; Anti-inflammatory effect: 1-2 hours.
Excretion
Mainly excreted in the urine (60-70%) as metabolites and their conjugates, with a smaller portion (10-20%) excreted in feces.
Half life
Approximately 2-4 hours, with some variability depending on individual metabolism.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are typically reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes (e.g., CYP2C9 and CYP2C19) to inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to doxolator or any excipients, or other NSAIDs (e.g., aspirin, ibuprofen)
- Active or history of recurrent peptic ulcer or gastrointestinal bleeding
- Severe heart failure, renal impairment, or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Diuretics
May reduce the natriuretic effect of diuretics and increase the risk of renal impairment.
Methotrexate
May increase methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE Inhibitors / Angiotensin Receptor Blockers
May reduce the antihypertensive effect and increase the risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In rare cases, more severe effects like acute renal failure, hepatic dysfunction, hypotension, respiratory depression, and coma may occur. Management involves symptomatic and supportive treatment. Gastric lavage or activated charcoal may be considered within the first hour of ingestion. Monitor vital signs and renal function.
Pregnancy & Lactation
Doxolator should be avoided during the third trimester of pregnancy due to potential risks to the fetus, including premature closure of the ductus arteriosus and renal dysfunction. During the first and second trimesters, use only if clearly needed and the potential benefit outweighs the risk. Small amounts of doxolator may pass into breast milk; consult a doctor before breastfeeding.
Side Effects
Contraindications
- Known hypersensitivity to doxolator or any excipients, or other NSAIDs (e.g., aspirin, ibuprofen)
- Active or history of recurrent peptic ulcer or gastrointestinal bleeding
- Severe heart failure, renal impairment, or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Diuretics
May reduce the natriuretic effect of diuretics and increase the risk of renal impairment.
Methotrexate
May increase methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE Inhibitors / Angiotensin Receptor Blockers
May reduce the antihypertensive effect and increase the risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In rare cases, more severe effects like acute renal failure, hepatic dysfunction, hypotension, respiratory depression, and coma may occur. Management involves symptomatic and supportive treatment. Gastric lavage or activated charcoal may be considered within the first hour of ingestion. Monitor vital signs and renal function.
Pregnancy & Lactation
Doxolator should be avoided during the third trimester of pregnancy due to potential risks to the fetus, including premature closure of the ductus arteriosus and renal dysfunction. During the first and second trimesters, use only if clearly needed and the potential benefit outweighs the risk. Small amounts of doxolator may pass into breast milk; consult a doctor before breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved by national regulatory authorities
Patent Status
Patented
Clinical Trials
Ongoing phase IV post-marketing surveillance studies are evaluating the long-term safety and efficacy of Doxolator in diverse patient populations.
Lab Monitoring
- Complete Blood Count (CBC) (especially with long-term use)
- Renal function tests (serum creatinine, BUN)
- Liver function tests (ALT, AST)
- Blood pressure monitoring
Doctor Notes
- Counsel patients on the importance of taking Doxolator with food to mitigate GI adverse events.
- Evaluate cardiovascular risk factors and GI bleeding history before initiating long-term therapy.
- Monitor renal function, especially in elderly patients or those with pre-existing renal impairment.
Patient Guidelines
- Take with food or milk to prevent stomach upset.
- Do not exceed the prescribed dose or duration of treatment.
- Avoid concomitant use with other NSAIDs or aspirin without consulting a doctor.
- Report any signs of gastrointestinal bleeding (black, tarry stools, vomiting blood) immediately.
- If you experience dizziness or drowsiness, avoid driving or operating heavy machinery.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Doxolator may cause dizziness, drowsiness, or visual disturbances in some individuals. Patients should be advised not to drive or operate machinery if they experience these side effects.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid excessive alcohol consumption, as it may increase the risk of stomach issues.
- If you have a history of heart conditions, discuss alternatives with your doctor.
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