Easium
Generic Name
Easium
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| easium 5 mg tablet | ৳ 0.69 | ৳ 27.60 |
Description
Overview of the medicine
Easium 5 mg Tablet is a non-benzodiazepine anxiolytic indicated for the short-term treatment of generalized anxiety disorder and insomnia. It works by enhancing the activity of GABA, a neurotransmitter in the brain, leading to a calming effect.
Uses & Indications
Dosage
Adults
For anxiety: 5 mg once daily, adjusted up to 10 mg daily if needed. For insomnia: 5 mg at bedtime.
Elderly
Lower initial dose recommended, typically 2.5 mg once daily, due to increased sensitivity and slower metabolism.
Renal_impairment
Use with caution; dose reduction may be necessary. Not recommended for severe impairment.
How to Take
Take orally with water, with or without food. For insomnia, take shortly before bedtime.
Mechanism of Action
Easium selectively binds to GABA-A receptors, potentiating the inhibitory effects of GABA, primarily at α1, α2, and α3 subunits. This leads to anxiolytic, sedative, hypnotic, and muscle relaxant properties.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly excreted in urine as inactive metabolites.
Half life
Approximately 6-8 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via CYP450 enzymes.
Side Effects
Contraindications
- •Hypersensitivity to Easium or any component of the formulation
- •Myasthenia gravis
- •Severe respiratory insufficiency
- •Sleep apnea syndrome
Drug Interactions
Alcohol
Enhanced sedative effects, increased risk of CNS depression.
Opioids
Increased risk of sedation, respiratory depression, coma, and death. Avoid concomitant use.
CYP450 inhibitors (e.g., ketoconazole, erythromycin)
May increase Easium plasma concentrations.
Other CNS depressants (e.g., antidepressants, antipsychotics, antihistamines)
Additive CNS depressant effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, ataxia, and respiratory depression. Management involves supportive care and gastric lavage if appropriate. Flumazenil may be considered in severe cases.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the first trimester, due to potential risk of congenital malformations. Use with caution during lactation; may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Pending
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Global Brand Names
International brand names for this medicine
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