Ectover
Generic Name
Etodolac
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ectover 6 mg tablet | ৳ 10.00 | ৳ 100.00 |
| ectover 12 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Ectover (Etodolac) is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis and rheumatoid arthritis.
Uses & Indications
Dosage
Adults
Osteoarthritis and Rheumatoid Arthritis: 300 mg two or three times daily, or 400-500 mg two times daily. Extended-release tablets: 400-1000 mg once daily. Max 1200 mg/day. Acute Pain: 200-400 mg every 6-8 hours as needed. Max 1200 mg/day.
Elderly
Lower doses may be required, and patients should be monitored for adverse effects. Initial dose typically 600 mg daily in divided doses, reducing if necessary.
Renal_impairment
Use with caution; consider lower doses and monitor renal function. Not recommended in severe renal impairment.
How to Take
Take orally, preferably with food or milk to reduce gastrointestinal upset. Swallow whole with water, do not crush or chew extended-release tablets.
Mechanism of Action
Etodolac acts as a non-selective inhibitor of cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in prostaglandin synthesis. By inhibiting these enzymes, it reduces the production of prostaglandins, thereby exerting its anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Analgesic effect within 30-60 minutes.
Excretion
Primarily excreted in the urine (about 70% as metabolites, 1% as unchanged drug); some excretion in feces.
Half life
Approximately 6-7 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract; absolute bioavailability is about 100%. Peak plasma concentrations occur within 1-2 hours.
Metabolism
Extensively metabolized in the liver via hydroxylation and glucuronidation. Active metabolites are formed.
Side Effects
Contraindications
- Known hypersensitivity to Etodolac or any component of the formulation
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- For the treatment of peri-operative pain in the setting of coronary artery bypass graft surgery
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
ACE Inhibitors and Angiotensin II Receptor Blockers
Increased risk of renal impairment and reduced antihypertensive effect.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within the first hour of ingestion. Monitor renal function and electrolyte balance.
Pregnancy & Lactation
Pregnancy: Use in the third trimester of pregnancy should be avoided due to the risk of premature closure of the fetal ductus arteriosus. Use in early pregnancy only if clearly needed and the potential benefit outweighs the risk. Lactation: Etodolac is excreted in human milk. A decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Known hypersensitivity to Etodolac or any component of the formulation
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- For the treatment of peri-operative pain in the setting of coronary artery bypass graft surgery
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
ACE Inhibitors and Angiotensin II Receptor Blockers
Increased risk of renal impairment and reduced antihypertensive effect.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within the first hour of ingestion. Monitor renal function and electrolyte balance.
Pregnancy & Lactation
Pregnancy: Use in the third trimester of pregnancy should be avoided due to the risk of premature closure of the fetal ductus arteriosus. Use in early pregnancy only if clearly needed and the potential benefit outweighs the risk. Lactation: Etodolac is excreted in human milk. A decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, check packaging for exact details.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Various clinical trials have established the efficacy and safety of Etodolac in conditions like osteoarthritis, rheumatoid arthritis, and acute pain.
Lab Monitoring
- Complete Blood Count for signs of anemia or bleeding
- Liver function tests periodically, especially with long-term use
- Renal function tests periodically, especially in elderly or those with risk factors for renal impairment
Doctor Notes
- Counsel patients on potential GI and cardiovascular risks.
- Consider prescribing a proton pump inhibitor for patients at high risk of GI complications, especially with long-term use.
- Monitor renal function and blood pressure in patients on chronic therapy.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Take with food or milk to minimize stomach upset.
- Report any signs of unusual bleeding, black/tarry stools, or severe stomach pain immediately.
- Avoid alcohol and other NSAIDs unless advised by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Ectover may cause dizziness, drowsiness, or visual disturbances in some patients. If these symptoms occur, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy diet and regular exercise suitable for your condition.
- Avoid smoking and excessive alcohol consumption, as these can exacerbate GI side effects.
- Discuss alternative pain management strategies with your doctor if long-term NSAID use is a concern.
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