Adults

Not directly applicable for 'pediatric drop' form. For pediatric patients (infants 3 months to children <40 kg): 20-50 mg/kg/day in 2-3 divided doses. For severe infections, up to 60 mg/kg/day may be given. Specific dose and duration should be determined by a physician. Example: 1.25 ml (125 mg) 2-3 times daily.

Elderly

Not applicable for this pediatric formulation.

Renal_impairment

Dosage adjustment is necessary for patients with severe renal impairment (creatinine clearance < 30 ml/min). Consult a physician for specific recommendations.

Onset

Clinical effects usually seen within 30-60 minutes after administration.

Excretion

Mainly excreted unchanged in the urine via renal tubular secretion and glomerular filtration. A small amount is excreted in feces.

Half life

Approximately 1 to 1.5 hours in adults with normal renal function; longer in neonates and those with renal impairment.

Absorption

Rapidly and well absorbed from the gastrointestinal tract, especially when taken orally. Peak plasma concentrations are achieved within 1-2 hours.

Metabolism

Approximately 10-25% of the dose is metabolized to inactive metabolites, primarily in the liver.

Probenecid

Concomitant use with probenecid is not recommended as it decreases the renal tubular secretion of amoxicillin, leading to increased and prolonged blood levels of amoxicillin.

Allopurinol

Concomitant administration of allopurinol during treatment with amoxicillin may increase the likelihood of allergic skin reactions.

Methotrexate

Penicillins may reduce the excretion of methotrexate, potentially increasing toxicity.

Tetracyclines

Tetracyclines and other bacteriostatic drugs may interfere with the bactericidal effects of penicillin and should be avoided.

Oral Anticoagulants

Prolongation of prothrombin time (INR) has been reported in patients receiving amoxicillin and oral anticoagulants. Careful monitoring is necessary.