Erybac
Generic Name
Erythromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| erybac 125 mg suspension | ৳ 84.76 | N/A |
Description
Overview of the medicine
Erybac 125 mg Suspension is an antibiotic from the macrolide class, used to treat various bacterial infections, especially in patients who are allergic to penicillin. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Adult dosage typically ranges from 250 mg to 500 mg every 6 hours, or 500 mg to 1 g every 12 hours, depending on the infection severity. This 125 mg suspension is primarily for pediatric use.
Elderly
Dosage adjustments are generally not necessary in elderly patients unless there is severe hepatic impairment.
Renal_impairment
No dosage adjustment is usually required for mild to moderate renal impairment. For severe impairment (CrCl <10 ml/min), a reduction to 50-75% of the usual dose may be considered.
How to Take
Oral administration. Shake the suspension well before each use. Can be taken with or without food, but taking it with food may reduce gastrointestinal upset. Complete the full course of treatment as prescribed, even if symptoms improve.
Mechanism of Action
Erythromycin binds to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting protein synthesis without affecting nucleic acid synthesis. This leads to a bacteriostatic effect, though it can be bactericidal at high concentrations or against highly susceptible organisms.
Pharmacokinetics
Onset
Typically within 1-2 hours.
Excretion
Mainly via bile and feces, with a small amount excreted in urine.
Half life
Approximately 1.5 to 2 hours.
Absorption
Well absorbed from the gastrointestinal tract, though absorption can be variable and affected by food. Ester forms (e.g., erythromycin estolate) are better absorbed.
Metabolism
Primarily hepatic, via CYP3A4 enzymes, to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to erythromycin or any macrolide antibiotic
- Co-administration with terfenadine, astemizole, cisapride, pimozide, or colchicine (due to risk of cardiac arrhythmias or severe toxicity)
- Pre-existing hepatic disease
Drug Interactions
Warfarin
Potentiation of anticoagulant effect, leading to increased bleeding risk.
Colchicine
Increased exposure to colchicine, leading to severe toxicity.
Theophylline
Increased serum concentration of theophylline, leading to toxicity.
Statins (e.g., simvastatin, lovastatin)
Increased risk of myopathy/rhabdomyolysis due to elevated statin levels.
Benzodiazepines (e.g., midazolam, triazolam)
Increased sedative effect.
Terfenadine, Astemizole, Cisapride, Pimozide
Increased risk of QT prolongation and serious cardiac arrhythmias.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard unused portion after the specified period (e.g., 7 or 14 days).
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and abdominal discomfort. Acute pancreatitis and reversible hearing loss may also occur. Treatment is supportive, focusing on gastric lavage and symptomatic management. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe, but use only if clearly needed. Erythromycin is excreted in breast milk; caution is advised, but usually compatible with breastfeeding with monitoring for infant side effects.
Side Effects
Contraindications
- Hypersensitivity to erythromycin or any macrolide antibiotic
- Co-administration with terfenadine, astemizole, cisapride, pimozide, or colchicine (due to risk of cardiac arrhythmias or severe toxicity)
- Pre-existing hepatic disease
Drug Interactions
Warfarin
Potentiation of anticoagulant effect, leading to increased bleeding risk.
Colchicine
Increased exposure to colchicine, leading to severe toxicity.
Theophylline
Increased serum concentration of theophylline, leading to toxicity.
Statins (e.g., simvastatin, lovastatin)
Increased risk of myopathy/rhabdomyolysis due to elevated statin levels.
Benzodiazepines (e.g., midazolam, triazolam)
Increased sedative effect.
Terfenadine, Astemizole, Cisapride, Pimozide
Increased risk of QT prolongation and serious cardiac arrhythmias.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard unused portion after the specified period (e.g., 7 or 14 days).
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and abdominal discomfort. Acute pancreatitis and reversible hearing loss may also occur. Treatment is supportive, focusing on gastric lavage and symptomatic management. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe, but use only if clearly needed. Erythromycin is excreted in breast milk; caution is advised, but usually compatible with breastfeeding with monitoring for infant side effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 24-36 months for unopened product. Once reconstituted, 7-14 days when stored in a refrigerator.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Expired (generic available)
WHO Essential Medicine
YesClinical Trials
Erythromycin has been extensively studied in numerous clinical trials since its discovery, establishing its efficacy and safety profile for various bacterial infections. Ongoing research may explore new indications or formulations.
Lab Monitoring
- Liver function tests (especially in prolonged therapy or pre-existing hepatic disease)
- Renal function tests (in severe renal impairment)
- Prothrombin time (for patients on warfarin)
Doctor Notes
- Emphasize completing the full course of antibiotics to prevent resistance.
- Advise patients on potential GI side effects and strategies to mitigate them (e.g., taking with food).
- Monitor for signs of cholestatic hepatitis or cardiac arrhythmias, especially with concomitant medications.
Patient Guidelines
- Take the full course of medicine as prescribed, even if you feel better.
- Shake the suspension well before each use.
- Do not share your medicine with others.
- Inform your doctor about all other medications you are taking.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Erythromycin generally does not impair the ability to drive or operate machinery. However, if you experience side effects like dizziness, avoid driving.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Stay hydrated by drinking plenty of fluids.
- Avoid alcohol consumption during treatment as it may exacerbate GI side effects.
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