Take the tablet orally, preferably on an empty stomach (1 hour before or 2 hours after meals) for optimal absorption of erythromycin base/stearate. However, it can be taken with food if gastrointestinal upset occurs. Swallow the tablet whole with a glass of water, do not chew or crush. Complete the full course of medication even if symptoms improve.

Erythromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing translocation of peptide chains. This action is primarily bacteriostatic, but can be bactericidal at higher concentrations or against highly susceptible organisms.

• •Hypersensitivity to erythromycin or any other macrolide antibiotic
• •Pre-existing liver disease
• •Concomitant use with terfenadine, astemizole, cisapride, pimozide (due to risk of QT prolongation and cardiac arrhythmias)
• •Concomitant use with statins metabolized by CYP3A4 (e.g., simvastatin, lovastatin) due to increased risk of myopathy/rhabdomyolysis

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Symptoms of overdose may include severe gastrointestinal upset (nausea, vomiting, diarrhea, abdominal pain), hearing loss (reversible), and liver toxicity. Management is primarily supportive, including gastric lavage or activated charcoal if recent ingestion, and monitoring vital signs.

Pregnancy Category B. Generally considered safe during pregnancy. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential adverse effects like diarrhea or thrush. Consult a doctor.