esmax
Generic Name
Esomeprazole Magnesium
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esmax 20 mg capsule | ৳ 8.50 | ৳ 85.00 |
Description
Overview of the medicine
Esmax 20 mg capsule contains Esomeprazole Magnesium, a proton pump inhibitor used to reduce the amount of acid produced in the stomach. It treats conditions such as GERD, erosive esophagitis, and ulcers.
Uses & Indications
Dosage
Adults
Usually 20 mg or 40 mg once daily, depending on the condition. For GERD, typically 20-40 mg once daily for 4-8 weeks. For H. pylori eradication, 20 mg twice daily for 7-10 days with antibiotics.
Elderly
No dosage adjustment generally required, but caution in severely impaired hepatic function.
Renal_impairment
No dosage adjustment is needed for patients with impaired renal function.
How to Take
Take orally, at least one hour before a meal. Swallow the capsule whole with water. Do not chew or crush.
Mechanism of Action
Esomeprazole selectively inhibits the H+/K+-ATPase (proton pump) in the parietal cells of the stomach, thereby blocking the final step of acid secretion.
Pharmacokinetics
Onset
Onset of acid suppression within 1 hour.
Excretion
Metabolites are primarily excreted in the urine (approx. 80%) and in the feces (approx. 20%).
Half life
Plasma half-life is approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 64% at 20 mg and increases to 89% with repeated dosing.
Metabolism
Extensively metabolized in the liver via the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Co-administration with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time, monitor carefully.
Nelfinavir
Coadministration is contraindicated due to decreased nelfinavir plasma levels.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel. Use with caution or consider alternative.
Methotrexate
Increased methotrexate levels, consider temporary withdrawal of PPI.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal disturbances and fatigue. Treatment is symptomatic and supportive. Esomeprazole is highly protein-bound and not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk, use with caution.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Co-administration with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time, monitor carefully.
Nelfinavir
Coadministration is contraindicated due to decreased nelfinavir plasma levels.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel. Use with caution or consider alternative.
Methotrexate
Increased methotrexate levels, consider temporary withdrawal of PPI.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal disturbances and fatigue. Treatment is symptomatic and supportive. Esomeprazole is highly protein-bound and not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk, use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated its efficacy and safety in various acid-related disorders.
Lab Monitoring
- Magnesium levels (especially with prolonged use or with other magnesium-lowering drugs)
- Bone mineral density (for long-term use)
Doctor Notes
- Advise patients on lifestyle modifications to complement therapy.
- Monitor magnesium levels and bone density for patients on long-term PPI therapy.
Patient Guidelines
- Take as directed by your doctor, usually before a meal.
- Do not stop taking the medicine abruptly without consulting your doctor.
- Report any unusual or severe side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods that worsen acid reflux, such as spicy foods, fatty foods, caffeine, and alcohol.
- Eat smaller, more frequent meals. Avoid lying down immediately after eating.
- Maintain a healthy weight.
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