Adults

Usually 20 mg or 40 mg once daily, depending on the condition. For GERD, typically 20-40 mg once daily for 4-8 weeks. For H. pylori eradication, 20 mg twice daily for 7-10 days with antibiotics.

Elderly

No dosage adjustment generally required, but caution in severely impaired hepatic function.

Renal_impairment

No dosage adjustment is needed for patients with impaired renal function.

Onset

Onset of acid suppression within 1 hour.

Excretion

Metabolites are primarily excreted in the urine (approx. 80%) and in the feces (approx. 20%).

Half life

Plasma half-life is approximately 1-1.5 hours.

Absorption

Rapidly absorbed after oral administration. Bioavailability is approximately 64% at 20 mg and increases to 89% with repeated dosing.

Metabolism

Extensively metabolized in the liver via the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and CYP3A4.

Warfarin

Increased INR and prothrombin time, monitor carefully.

Nelfinavir

Coadministration is contraindicated due to decreased nelfinavir plasma levels.

Clopidogrel

May reduce the antiplatelet effect of clopidogrel. Use with caution or consider alternative.

Methotrexate

Increased methotrexate levels, consider temporary withdrawal of PPI.