Esogut
Generic Name
Esomeprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esogut 5 mg pediatric drop | ৳ 25.00 | N/A |
Description
Overview of the medicine
Esogut 5 mg Pediatric Drop contains Esomeprazole, a proton pump inhibitor, used to reduce the amount of acid produced in the stomach. It is specifically formulated for pediatric use to treat acid-related conditions.
Uses & Indications
Dosage
Adults
Not applicable for pediatric drop formulation; adult dosing is typically 20-40 mg daily.
Elderly
Not applicable for pediatric drop formulation.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Caution with severe impairment.
How to Take
Administer orally, usually 30-60 minutes before a meal. The drop can be mixed with a small amount of water, apple juice, or soft food (e.g., applesauce) immediately before administration. Do not chew or crush.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase (proton pump) in the gastric parietal cells. This irreversible inhibition blocks the final step in acid secretion, leading to a sustained reduction in gastric acid production.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted in the urine (about 80%) and feces (about 20%) as metabolites.
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 1-2 hours. Bioavailability increases with repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily by CYP2C19 and to a lesser extent by CYP3A4.
Side Effects
Contraindications
- •Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- •Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased systemic exposure to digoxin.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Methotrexate
Possible increased methotrexate levels, especially with high doses.
Atazanavir/Nelfinavir
Reduced plasma concentrations of atazanavir/nelfinavir.
Diazepam/Phenytoin/Warfarin
Increased plasma concentrations of these drugs (CYP2C19 substrates).
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of the reach of children.
Overdose
Limited experience with overdose. Symptoms are generally mild and transient, including drowsiness, confusion, blurred vision, tachycardia, nausea, vomiting, sweating, headache, dry mouth. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnant women should only be when clearly needed. Esomeprazole is excreted in human breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture. Check expiry date on packaging.
Availability
Available in pharmacies
Approval Status
Approved by regulatory bodies worldwide
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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