Take orally with food or milk to reduce gastrointestinal upset.

Etodolac inhibits cyclooxygenase (COX) enzymes, particularly showing preferential inhibition of COX-2, thereby reducing the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever.

• •Hypersensitivity to etodolac or other NSAIDs
• •History of aspirin-induced asthma, urticaria, or allergic-type reactions
• •Active gastrointestinal bleeding or peptic ulcer disease
• •Severe renal or hepatic impairment
• •Third trimester of pregnancy
• •Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within 1 hour of ingestion.

Pregnancy: Avoid in the third trimester due to risk of premature closure of the ductus arteriosus. Use with caution in the first and second trimesters only if potential benefit outweighs risk. Lactation: Small amounts may pass into breast milk; generally not recommended.