Etoricoxib
Generic Name
Etoricoxib 60 mg Tablet
Manufacturer
Multiple manufacturers globally
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| etoricoxib 60 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor belonging to the class of NSAIDs, used for the symptomatic relief of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and for the treatment of acute pain and primary dysmenorrhea.
Uses & Indications
Dosage
Adults
Osteoarthritis: 30 mg or 60 mg once daily. Rheumatoid arthritis/Ankylosing spondylitis: 90 mg once daily. Acute gouty arthritis: 120 mg once daily for maximum 8 days. Acute pain/Primary dysmenorrhea: 60 mg or 90 mg once daily for maximum 8 days. The 60 mg is common for acute pain and osteoarthritis.
Elderly
No dose adjustment generally required, but caution is advised in elderly patients due to increased risk of side effects.
Renal_impairment
Mild to moderate renal impairment: No dose adjustment. Severe renal impairment (creatinine clearance <30 mL/min): Not recommended.
How to Take
Orally, with or without food. Taking with food may slightly delay absorption, but it does not affect the extent of absorption.
Mechanism of Action
Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2), an enzyme responsible for the synthesis of prostaglandins, which are mediators of pain and inflammation. By inhibiting COX-2, it reduces pain and inflammation while potentially sparing COX-1 mediated protective effects in the gastrointestinal tract.
Pharmacokinetics
Onset
Within 24 minutes for acute pain, peak effect within 1-2 hours.
Excretion
Mainly via urine (70%) and feces (20%) as metabolites, very little unchanged drug is excreted.
Half life
Approximately 22 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in approximately 1 hour.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 enzymes (CYP3A4) to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to etoricoxib or any component of the tablet
- •Active peptic ulceration or gastrointestinal bleeding
- •Severe hepatic dysfunction
- •Severe renal dysfunction (creatinine clearance <30 mL/min)
- •Inflammatory bowel disease
- •Congestive heart failure (NYHA II-IV)
- •Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- •Uncontrolled hypertension
- •Pregnancy and lactation
Drug Interactions
Lithium
Increased plasma levels of lithium, leading to toxicity.
Rifampicin
Decreased plasma levels of etoricoxib.
Methotrexate
Increased plasma levels of methotrexate, leading to toxicity.
Oral contraceptives
Increased plasma concentrations of ethinyl estradiol.
Cyclosporine, Tacrolimus
Increased nephrotoxicity.
Warfarin and other anticoagulants
Increased risk of bleeding.
ACE inhibitors / Angiotensin II antagonists / Diuretics
Reduced antihypertensive effect, increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote. Dialysis is unlikely to be effective in removing etoricoxib.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation. NSAIDs, including etoricoxib, should be avoided in the third trimester of pregnancy due to the risk of premature closure of the ductus arteriosus and fetal renal dysfunction. A decision must be made whether to discontinue nursing or to discontinue the drug.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory bodies (e.g., EMA, FDA in some regions, DGDA)
Patent Status
Expired in most regions; generic versions available
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Global Brand Names
International brand names for this medicine
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