Famiclav
Generic Name
Amoxicillin + Clavulanic Acid 125 mg / 5 ml Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| famiclav 125 mg suspension | ৳ 265.00 | N/A |
Description
Overview of the medicine
Famiclav 125 mg Suspension is an antibiotic medication combining amoxicillin and clavulanic acid. Amoxicillin is a penicillin-type antibiotic that fights bacteria, and clavulanic acid is a beta-lactamase inhibitor that prevents bacteria from destroying amoxicillin, making the antibiotic more effective against a wider range of bacteria. It is used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Adults: 250 mg/125 mg to 500 mg/125 mg three times daily, depending on severity and type of infection. Note: 125 mg suspension is typically for pediatric use.
Elderly
No specific dosage adjustment required unless there is renal impairment.
Renal_impairment
Dosage adjustment is necessary based on creatinine clearance. For severe impairment (CrCl < 30 ml/min), consult a physician for specific recommendations, often extended intervals or reduced dose.
How to Take
Reconstitute the dry powder with boiled and cooled water as directed on the label. Shake the bottle well before each use. Take the medicine orally, with or without food. Taking it with food may help reduce potential gastrointestinal upset. Use the provided measuring spoon or cup for accurate dosing.
Mechanism of Action
Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis. Clavulanic acid is a beta-lactamase inhibitor that irreversibly binds to and inactivates beta-lactamase enzymes produced by resistant bacteria, thereby extending the antibacterial spectrum of amoxicillin.
Pharmacokinetics
Onset
Antibacterial effect typically begins within 1 hour of administration.
Excretion
Both components are primarily excreted unchanged in the urine, mainly by tubular secretion and glomerular filtration.
Half life
Amoxicillin has an elimination half-life of approximately 1-1.3 hours. Clavulanic acid has an elimination half-life of approximately 1 hour.
Absorption
Both amoxicillin and clavulanic acid are well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are achieved within approximately 1-2 hours.
Metabolism
Amoxicillin is minimally metabolized; about 10-25% of clavulanic acid is metabolized to inactive metabolites.
Side Effects
Contraindications
- History of hypersensitivity to penicillin or other beta-lactam antibiotics (e.g., cephalosporins)
- Previous history of amoxicillin-clavulanate associated jaundice or hepatic dysfunction
Drug Interactions
Probenecid
Increases amoxicillin blood levels by reducing renal tubular secretion.
Allopurinol
Increased incidence of rash, particularly in hyperuricemic patients.
Methotrexate
May increase methotrexate toxicity due to reduced renal excretion.
Oral contraceptives
May reduce the efficacy of oral contraceptives; advise additional non-hormonal contraception.
Warfarin and other oral anticoagulants
May prolong prothrombin time; monitor INR closely.
Storage
Store the dry powder below 30°C in a dry place, away from direct sunlight. Once reconstituted, store the suspension in a refrigerator (2-8°C) and do not freeze.
Overdose
Symptoms of overdose may include gastrointestinal symptoms (nausea, vomiting, diarrhea), fluid and electrolyte imbalance, and crystalluria (renal failure in severe cases). Management is symptomatic and supportive, with attention to fluid and electrolyte balance. Amoxicillin/clavulanate can be removed from circulation by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Both amoxicillin and clavulanic acid are excreted into human milk in small amounts; use with caution during breastfeeding.
Side Effects
Contraindications
- History of hypersensitivity to penicillin or other beta-lactam antibiotics (e.g., cephalosporins)
- Previous history of amoxicillin-clavulanate associated jaundice or hepatic dysfunction
Drug Interactions
Probenecid
Increases amoxicillin blood levels by reducing renal tubular secretion.
Allopurinol
Increased incidence of rash, particularly in hyperuricemic patients.
Methotrexate
May increase methotrexate toxicity due to reduced renal excretion.
Oral contraceptives
May reduce the efficacy of oral contraceptives; advise additional non-hormonal contraception.
Warfarin and other oral anticoagulants
May prolong prothrombin time; monitor INR closely.
Storage
Store the dry powder below 30°C in a dry place, away from direct sunlight. Once reconstituted, store the suspension in a refrigerator (2-8°C) and do not freeze.
Overdose
Symptoms of overdose may include gastrointestinal symptoms (nausea, vomiting, diarrhea), fluid and electrolyte imbalance, and crystalluria (renal failure in severe cases). Management is symptomatic and supportive, with attention to fluid and electrolyte balance. Amoxicillin/clavulanate can be removed from circulation by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Both amoxicillin and clavulanic acid are excreted into human milk in small amounts; use with caution during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 24-36 months (unopened). Reconstituted suspension: 7-10 days when stored in a refrigerator (2-8°C).
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of amoxicillin/clavulanate combination for various bacterial infections. Ongoing post-marketing surveillance continues to monitor safety profiles.
Lab Monitoring
- Liver function tests (LFTs) if treatment is prolonged or in patients with a history of hepatic dysfunction
- Renal function in patients with renal impairment or during prolonged high-dose therapy
Doctor Notes
- Advise patients about the importance of completing the full course of therapy.
- Caution patients about potential allergic reactions, especially those with a history of penicillin allergy.
- Monitor liver function in patients with pre-existing hepatic impairment or during prolonged treatment.
- Counsel on proper reconstitution and storage of the suspension.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve, to prevent recurrence and antibiotic resistance.
- Shake the suspension well before each use.
- Use the provided measuring device for accurate dosing.
- Discard any unused portion after the specified period (usually 7-10 days after reconstitution).
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally, this medicine does not impair ability to drive or operate machinery. However, if side effects like dizziness or headache occur, avoid such activities.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Report any severe or persistent side effects to your doctor.
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