Famiclav
Generic Name
Amoxicillin and Clavulanic Acid
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| famiclav 500 mg tablet | ৳ 60.00 | ৳ 420.00 |
Description
Overview of the medicine
Famiclav 500 mg Tablet is a combination antibiotic containing amoxicillin and clavulanic acid, used to treat a wide range of bacterial infections. Amoxicillin is a penicillin-type antibiotic that fights bacteria, and clavulanic acid prevents certain bacteria from becoming resistant to amoxicillin.
Uses & Indications
Dosage
Adults
The usual adult dose for Famiclav 500 mg Tablet is one 500 mg/125 mg tablet taken every 8 hours, or one 875 mg/125 mg tablet taken every 12 hours, depending on the severity and type of infection. Treatment duration is typically 7-10 days.
Elderly
No specific dose adjustment is required in elderly patients unless there is evidence of renal impairment.
Renal_impairment
Dose adjustments are necessary for patients with impaired renal function, based on creatinine clearance. Consult a physician for specific dosing recommendations.
How to Take
Take Famiclav 500 mg Tablet at the start of a meal to minimize potential gastrointestinal intolerance and to enhance absorption. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
Mechanism of Action
Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death. Clavulanic acid is a beta-lactamase inhibitor that irreversibly binds to and inactivates beta-lactamase enzymes produced by bacteria, thus protecting amoxicillin from degradation and extending its antibacterial spectrum.
Pharmacokinetics
Onset
Antibacterial effect typically begins within 1 hour of administration.
Excretion
Both amoxicillin and clavulanic acid are primarily eliminated via renal excretion (urine).
Half life
The elimination half-life for amoxicillin is approximately 1 to 1.5 hours, and for clavulanic acid, it is about 1 hour.
Absorption
Both amoxicillin and clavulanic acid are well absorbed from the gastrointestinal tract after oral administration, with clavulanic acid enhancing the absorption of amoxicillin. Peak plasma concentrations are achieved within 1 to 2 hours.
Metabolism
Amoxicillin undergoes limited metabolism in the liver. Clavulanic acid is extensively metabolized.
Side Effects
Contraindications
- Patients with a history of severe hypersensitivity reaction (e.g., anaphylaxis) to amoxicillin, clavulanic acid, any penicillin, or other beta-lactam antibiotics.
- Patients with a history of amoxicillin/clavulanate-associated jaundice or hepatic dysfunction.
- Patients with infectious mononucleosis, as it may increase the risk of erythematous rash.
Drug Interactions
Probenecid
Reduces renal tubular secretion of amoxicillin, leading to increased and prolonged blood levels of amoxicillin.
Allopurinol
Co-administration may increase the incidence of skin rash, especially in patients with hyperuricemia.
Methotrexate
Amoxicillin may reduce the renal excretion of methotrexate, potentially increasing its toxicity. Concurrent use should be carefully monitored.
Oral Contraceptives
Amoxicillin may reduce the efficacy of oral contraceptives. Advise patients to use additional non-hormonal contraception.
Mycophenolate Mofetil
Reduced pre-dose concentration of the active metabolite of mycophenolate mofetil observed with co-administration.
Warfarin and other oral anticoagulants
May prolong prothrombin time and increase the risk of bleeding. Close monitoring of INR is recommended.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of overdose, patients may experience gastrointestinal symptoms (e.g., abdominal pain, vomiting, diarrhea) and fluid and electrolyte imbalance. Crystalluria leading to renal failure has been observed. Treatment should be symptomatic and supportive. Gastric lavage may be performed, and adequate fluid intake should be maintained. Hemodialysis can effectively remove amoxicillin from the circulation.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed after consulting a doctor. Amoxicillin and clavulanic acid are excreted in breast milk; therefore, use with caution in nursing mothers and consult a physician.
Side Effects
Contraindications
- Patients with a history of severe hypersensitivity reaction (e.g., anaphylaxis) to amoxicillin, clavulanic acid, any penicillin, or other beta-lactam antibiotics.
- Patients with a history of amoxicillin/clavulanate-associated jaundice or hepatic dysfunction.
- Patients with infectious mononucleosis, as it may increase the risk of erythematous rash.
Drug Interactions
Probenecid
Reduces renal tubular secretion of amoxicillin, leading to increased and prolonged blood levels of amoxicillin.
Allopurinol
Co-administration may increase the incidence of skin rash, especially in patients with hyperuricemia.
Methotrexate
Amoxicillin may reduce the renal excretion of methotrexate, potentially increasing its toxicity. Concurrent use should be carefully monitored.
Oral Contraceptives
Amoxicillin may reduce the efficacy of oral contraceptives. Advise patients to use additional non-hormonal contraception.
Mycophenolate Mofetil
Reduced pre-dose concentration of the active metabolite of mycophenolate mofetil observed with co-administration.
Warfarin and other oral anticoagulants
May prolong prothrombin time and increase the risk of bleeding. Close monitoring of INR is recommended.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of overdose, patients may experience gastrointestinal symptoms (e.g., abdominal pain, vomiting, diarrhea) and fluid and electrolyte imbalance. Crystalluria leading to renal failure has been observed. Treatment should be symptomatic and supportive. Gastric lavage may be performed, and adequate fluid intake should be maintained. Hemodialysis can effectively remove amoxicillin from the circulation.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed after consulting a doctor. Amoxicillin and clavulanic acid are excreted in breast milk; therefore, use with caution in nursing mothers and consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture, when stored as per recommendations.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies globally
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Amoxicillin-clavulanic acid combination has been extensively studied and widely used globally for several decades. Clinical trials have established its efficacy and safety profile for various bacterial infections. Ongoing research focuses on its effectiveness against emerging resistant strains and in specific patient populations.
Lab Monitoring
- Periodic assessment of renal, hepatic, and hematopoietic function is advisable during prolonged therapy.
- Liver function tests (LFTs) should be monitored in patients with pre-existing hepatic impairment or those developing jaundice.
Doctor Notes
- Emphasize the importance of completing the full prescribed course to prevent treatment failure and antibiotic resistance.
- Counsel patients on potential gastrointestinal side effects and advise taking the medication with food.
- Be vigilant for signs of hypersensitivity reactions, especially in patients with a history of penicillin allergy.
- Monitor liver function tests in patients with pre-existing hepatic disease or if therapy is prolonged beyond 14 days.
Patient Guidelines
- Always complete the full course of medication as prescribed by your doctor, even if your symptoms improve sooner.
- Do not share this medicine with others, even if they have similar symptoms, as it may not be suitable for them.
- Report any severe or persistent side effects, such as severe diarrhea, skin rash, or yellowing of the skin/eyes, to your doctor immediately.
- Take this medicine with food to reduce stomach upset.
- Store the medicine as directed.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Famiclav 500 mg Tablet can cause side effects such as dizziness, which may affect your ability to drive or operate machinery. If you experience such effects, avoid driving or performing tasks requiring alertness.
Lifestyle Advice
- Drink plenty of fluids to help prevent crystalluria and maintain hydration, especially if you experience diarrhea.
- Practice good personal hygiene to help prevent the spread of infection and reinfection.
- Avoid alcohol consumption during the course of treatment, as it may worsen some side effects.
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