Fexona
Generic Name
Fexofenadine 180 mg tablet
Manufacturer
Opsonin Pharma Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fexona 180 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Fexona 180 mg tablet contains Fexofenadine, a non-drowsy antihistamine used to relieve symptoms of seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives). It works by blocking histamine H1 receptors, reducing allergic reactions like sneezing, runny nose, itchy eyes/nose/throat, and skin rash.
Uses & Indications
Dosage
Adults
Seasonal Allergic Rhinitis: 180 mg once daily. Chronic Idiopathic Urticaria: 180 mg once daily.
Elderly
No dosage adjustment generally required, but caution is advised.
Renal_impairment
Dosage adjustment may be considered (e.g., 60 mg once daily for moderate to severe renal impairment). Consult a physician.
How to Take
Fexona 180 mg tablet should be taken orally with water, preferably before a meal. Do not take with fruit juice as it may reduce absorption.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It binds to histamine H1 receptors without crossing the blood-brain barrier significantly, thereby blocking the action of histamine, which is responsible for allergic symptoms, with minimal central nervous system effects (e.g., drowsiness).
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted unchanged in feces (80%) and urine (10%)
Half life
11-15 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in 1-3 hours.
Metabolism
Minimally metabolized (approximately 5% hepatic metabolism)
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation.
Drug Interactions
Erythromycin or Ketoconazole
May increase fexofenadine plasma concentrations. Clinical significance is usually minimal but caution is advised.
Antacids containing aluminum and magnesium
May reduce the absorption of fexofenadine. Separate administration by at least 2 hours.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include drowsiness, dizziness, and dry mouth. Management is symptomatic and supportive, including gastric lavage and observation.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is unknown if fexofenadine is excreted in human milk; use with caution in nursing mothers. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation.
Drug Interactions
Erythromycin or Ketoconazole
May increase fexofenadine plasma concentrations. Clinical significance is usually minimal but caution is advised.
Antacids containing aluminum and magnesium
May reduce the absorption of fexofenadine. Separate administration by at least 2 hours.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include drowsiness, dizziness, and dry mouth. Management is symptomatic and supportive, including gastric lavage and observation.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is unknown if fexofenadine is excreted in human milk; use with caution in nursing mothers. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available, patent expired
Clinical Trials
Extensive clinical trials have established fexofenadine's efficacy and safety for allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- No routine lab monitoring is generally required.
- Liver and kidney function tests in patients with pre-existing impairment.
Doctor Notes
- Advise patients to avoid taking fexofenadine with fruit juices.
- Reassure patients about its non-sedating profile.
- Consider renal dose adjustment in patients with impaired kidney function.
Patient Guidelines
- Take as directed by your doctor.
- Do not take with fruit juice.
- Inform your doctor about all other medications you are taking.
- Do not exceed the recommended dose.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Fexofenadine is a non-drowsy antihistamine. However, individual responses may vary. If you experience drowsiness or dizziness, avoid driving or operating machinery.
Lifestyle Advice
- Avoid known allergens.
- Keep your living environment clean to minimize dust mites and pet dander.
- Consider using air purifiers.
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