Fexten
Generic Name
Fexofenadine Hydrochloride
Manufacturer
ACME Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fexten 60 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Fexofenadine is a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives). It helps alleviate sneezing, runny nose, itchy eyes/nose/throat, and skin rash/itching.
Uses & Indications
Dosage
Adults
For seasonal allergic rhinitis: 60 mg twice daily, or 180 mg once daily. For chronic idiopathic urticaria: 60 mg twice daily, or 180 mg once daily.
Elderly
No specific dose adjustment is recommended for elderly patients unless they have renal impairment.
Renal_impairment
For adults with impaired renal function (creatinine clearance ≤ 80 mL/min): initiate with 60 mg once daily.
How to Take
Take orally with water, with or without food. Avoid taking with fruit juices (e.g., grapefruit, orange, apple) as they may reduce the absorption and effectiveness of fexofenadine.
Mechanism of Action
Fexofenadine selectively antagonizes peripheral H1-receptors, thereby preventing the effects of histamine and reducing allergic symptoms.
Pharmacokinetics
Onset
Onset of action is approximately 1 hour.
Excretion
Approximately 80% is excreted in feces and 11% in urine, primarily as unchanged drug.
Half life
Elimination half-life ranges from 11 to 15 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 1-3 hours.
Metabolism
Minimally metabolized in the liver; approximately 5% of the dose undergoes hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any of the excipients.
- Patients with known allergic reactions to similar antihistamines.
Drug Interactions
Fruit Juices
Fruit juices (grapefruit, orange, apple) can reduce the bioavailability of fexofenadine; avoid taking fexofenadine with these juices.
Erythromycin and Ketoconazole
Concomitant use with erythromycin or ketoconazole has been shown to increase fexofenadine plasma concentrations, but without significant increase in adverse effects.
Aluminum and Magnesium Hydroxide Antacids
Concomitant administration with aluminum- or magnesium-containing antacids may reduce the bioavailability of fexofenadine. Separate administration by at least 2 hours.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Treatment should be symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted into breast milk; caution should be exercised when administering to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any of the excipients.
- Patients with known allergic reactions to similar antihistamines.
Drug Interactions
Fruit Juices
Fruit juices (grapefruit, orange, apple) can reduce the bioavailability of fexofenadine; avoid taking fexofenadine with these juices.
Erythromycin and Ketoconazole
Concomitant use with erythromycin or ketoconazole has been shown to increase fexofenadine plasma concentrations, but without significant increase in adverse effects.
Aluminum and Magnesium Hydroxide Antacids
Concomitant administration with aluminum- or magnesium-containing antacids may reduce the bioavailability of fexofenadine. Separate administration by at least 2 hours.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Treatment should be symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted into breast milk; caution should be exercised when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of fexofenadine for the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- Routine laboratory monitoring is generally not required during fexofenadine therapy.
Doctor Notes
- Advise patients to avoid taking fexofenadine with fruit juices.
- Consider dose adjustment in patients with renal impairment.
- Fexofenadine is a good option for patients requiring a non-sedating antihistamine.
Patient Guidelines
- Do not take Fexten-60 mg Tablet with fruit juices.
- Do not exceed the recommended dose.
- Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
- Discontinue use and consult your doctor if you experience any severe allergic reactions.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Fexofenadine is a non-sedating antihistamine, but some individuals may still experience drowsiness or dizziness. Exercise caution when driving or operating machinery until you know how Fexten-60 mg Tablet affects you.
Lifestyle Advice
- Identify and avoid exposure to known allergens that trigger your symptoms.
- Maintain adequate hydration.
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