Medicine Information

Fexten

Name: Fexten
Brand: Fexten
Rating: 4.5 (117 reviews)

Tablet120 mgAntihistaminesATC: R06AX26

Generic Name

Fexofenadine Hydrochloride

Manufacturer

MediCare Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
fexten 120 mg tablet	৳ 8.00	৳ 80.00

Description

Overview of the medicine

Fexten 120 mg Tablet contains fexofenadine hydrochloride, a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria.

Uses & Indications

Seasonal Allergic Rhinitis

Chronic Idiopathic Urticaria

Dosage

Adults

Seasonal Allergic Rhinitis: 120 mg or 180 mg once daily. Chronic Idiopathic Urticaria: 180 mg once daily.

Elderly

No specific dose adjustment required unless renal impairment is present.

Renal_impairment

For seasonal allergic rhinitis in patients with moderate to severe renal impairment (CrCl < 80 mL/min), the recommended starting dose is 60 mg once daily. For chronic idiopathic urticaria, 60 mg once daily.

How to Take

May be taken with or without food. Avoid taking with fruit juices (grapefruit, orange, apple) as they can reduce absorption.

Mechanism of Action

Fexofenadine is a selective peripheral H1-blocker. It inhibits histamine release and blocks histamine's action on H1 receptors, reducing allergic symptoms without significant central nervous system effects.

Pharmacokinetics

Onset

Approximately 1 hour

Excretion

Excreted mainly in the feces (80%) and urine (11%) primarily as unchanged drug.

Half life

About 14 hours (ranging 11-16 hours)

Absorption

Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached in 1-3 hours.

Metabolism

Minimally metabolized; primarily unchanged in feces and urine.

Side Effects

Contraindications

Hypersensitivity to fexofenadine or any component of the formulation.

Drug Interactions

Erythromycin, Ketoconazole

Can increase fexofenadine plasma concentrations. Co-administration should be avoided or monitored.

Antacids containing Aluminum and Magnesium

Can reduce fexofenadine absorption. Separate administration by at least 2 hours.

Storage

Store below 30°C in a dry place, away from light. Keep out of reach of children.

Overdose

Symptoms of overdose include drowsiness, dizziness, and dry mouth. Management is symptomatic and supportive; hemodialysis is not effective.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk, so caution advised during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box

Shelf Life

24-36 months

Availability

Pharmacies, Hospitals

Approval Status

Approved by regulatory authorities (e.g., FDA, DGDA)

Patent Status

Generic available (original patent expired)

Clinical Trials

Extensively studied in clinical trials demonstrating efficacy and safety for seasonal allergic rhinitis and chronic idiopathic urticaria across various populations.

Lab Monitoring

Generally, no specific lab monitoring required.

Doctor Notes

Advise patients to avoid taking fexofenadine with fruit juices as it can reduce drug efficacy.
For patients with renal impairment, dosage adjustment is necessary.

Patient Guidelines

Do not exceed the recommended dose.
Inform your doctor about all medications you are taking.
Avoid driving or operating machinery if you experience drowsiness.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.