Filodox
Generic Name
Doxofylline
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| filodox 100 mg syrup | ৳ 100.00 | N/A |
| filodox 200 mg tablet | ৳ 6.00 | ৳ 60.00 |
| filodox 400 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Filodox (Doxofylline) is a bronchodilator used for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD). It helps to relax the muscles of the airways, making it easier to breathe.
Uses & Indications
Dosage
Adults
Adults: 400 mg twice daily. In some cases, 200 mg three times daily may be sufficient.
Elderly
Elderly patients may require a reduced dose. Initial dose 200 mg twice daily.
Renal_impairment
Use with caution. Dosage adjustment may be required in severe renal impairment.
How to Take
Filodox tablets should be taken orally, with or without food. Syrup can be taken with water.
Mechanism of Action
Doxofylline exerts its bronchodilator effect by selectively inhibiting phosphodiesterase enzymes, leading to an increase in intracellular cyclic AMP (cAMP) and subsequent relaxation of bronchial smooth muscles. Unlike theophylline, it has a lower affinity for adenosine receptors, resulting in fewer cardiac and central nervous system side effects.
Pharmacokinetics
Onset
Bronchodilation starts within 30-60 minutes.
Excretion
Mainly excreted in urine as metabolites, with a small portion as unchanged drug.
Half life
Approximately 6-8 hours in adults.
Absorption
Rapidly absorbed after oral administration, peak plasma concentration reached within 1 hour.
Metabolism
Extensively metabolized in the liver, primarily by oxidation.
Side Effects
Contraindications
- Hypersensitivity to doxofylline or other xanthine derivatives
- Acute myocardial infarction
- Severe hypotension
- Lactating women
Drug Interactions
Cimetidine
May increase doxofylline plasma levels.
Erythromycin
May increase doxofylline plasma levels, requiring dose reduction.
Phenobarbital, Rifampicin, Phenytoin
May decrease doxofylline plasma levels.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, epigastric pain, restlessness, insomnia, headache, tachycardia, arrhythmia, and convulsions. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal. Maintain airway and cardiovascular function.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Contraindicated in lactating women.
Side Effects
Contraindications
- Hypersensitivity to doxofylline or other xanthine derivatives
- Acute myocardial infarction
- Severe hypotension
- Lactating women
Drug Interactions
Cimetidine
May increase doxofylline plasma levels.
Erythromycin
May increase doxofylline plasma levels, requiring dose reduction.
Phenobarbital, Rifampicin, Phenytoin
May decrease doxofylline plasma levels.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, epigastric pain, restlessness, insomnia, headache, tachycardia, arrhythmia, and convulsions. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal. Maintain airway and cardiovascular function.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Contraindicated in lactating women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in all pharmacies in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Doxofylline has been evaluated in various clinical trials demonstrating its efficacy and safety in bronchial asthma and COPD patients.
Lab Monitoring
- No routine lab monitoring is generally required. Monitor serum doxofylline levels if toxicity is suspected or in patients with impaired liver/renal function.
Doctor Notes
- Doxofylline is a potent bronchodilator with a favorable safety profile compared to theophylline. Monitor patient response, especially for those with cardiovascular comorbidities.
- Consider dose adjustment in hepatic or renal impairment.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop the medicine suddenly without consulting your doctor.
- Report any severe side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness; caution advised while driving or operating machinery.
Lifestyle Advice
- Avoid smoking, as it may reduce the effectiveness of this medicine.
- Maintain a healthy diet and regular exercise.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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