Fix-A DS
Generic Name
Cefixime
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fix a ds 400 mg capsule | ৳ 60.00 | ৳ 420.00 |
| fix a ds 200 mg suspension | ৳ 320.00 | N/A |
Description
Overview of the medicine
Fix-A DS (Cefixime) is a third-generation cephalosporin antibiotic used to treat various bacterial infections. It is effective against a wide range of gram-positive and gram-negative bacteria.
Uses & Indications
Dosage
Adults
Adults and children over 12 years or weighing more than 50 kg: 400 mg once daily or 200 mg every 12 hours for 7-14 days depending on the infection.
Elderly
No special dosage adjustment required unless severe renal impairment.
Renal_impairment
Dose adjustment required. CrCl 21-60 mL/min: 300 mg daily. CrCl < 20 mL/min: 200 mg daily.
How to Take
Fix-A DS tablets should be swallowed whole with water, with or without food. Taking it with food may reduce gastrointestinal discomfort.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Typically within 2-4 hours after oral administration.
Excretion
Mainly via renal excretion (glomerular filtration and tubular secretion) and some biliary excretion.
Half life
Average 3-4 hours, can be prolonged in renal impairment.
Absorption
Approximately 30-50% orally absorbed. Food can delay absorption but does not significantly affect the extent.
Metabolism
Not extensively metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or other cephalosporins
- History of severe hypersensitivity to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, leading to increased bleeding risk. Monitor coagulation parameters closely.
Nifedipine
Concurrent use may increase Cefixime absorption.
Carbamazepine
May increase carbamazepine levels with concomitant use.
Oral Contraceptives
May reduce the efficacy of oral contraceptives (though evidence is not strong for all antibiotics, advise caution).
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or other cephalosporins
- History of severe hypersensitivity to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, leading to increased bleeding risk. Monitor coagulation parameters closely.
Nifedipine
Concurrent use may increase Cefixime absorption.
Carbamazepine
May increase carbamazepine levels with concomitant use.
Oral Contraceptives
May reduce the efficacy of oral contraceptives (though evidence is not strong for all antibiotics, advise caution).
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the manufacturing date.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established cefixime's efficacy and safety for indicated bacterial infections. Post-marketing surveillance continues.
Lab Monitoring
- Complete Blood Count (CBC) with differential if treatment is prolonged
- Renal function tests (BUN, creatinine) in patients with pre-existing renal impairment or during prolonged therapy
- Liver function tests (LFTs) periodically, especially in patients with hepatic dysfunction.
Doctor Notes
- Confirm bacterial infection before prescribing.
- Advise patients on the importance of completing the full course.
- Monitor for signs of C. difficile-associated diarrhea.
Patient Guidelines
- Complete the full course of antibiotics, even if symptoms improve, to prevent antibiotic resistance.
- Do not share this medication with others.
- Store at room temperature away from moisture and heat.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, if side effects like dizziness occur, patients should avoid such activities.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.