Fluact
Generic Name
Fluoxetine
Manufacturer
MediPharm Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fluact 50 mg capsule | ৳ 8.00 | N/A |
Description
Overview of the medicine
Fluact 50 mg Capsule is primarily used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, and bulimia nervosa. It belongs to a class of drugs known as Selective Serotonin Reuptake Inhibitors (SSRIs) that help restore the balance of serotonin in the brain.
Uses & Indications
Dosage
Adults
Major Depressive Disorder: Initially 20 mg once daily, may be increased to 60 mg daily. OCD: Initially 20 mg daily, may be increased to 60 mg daily. Bulimia Nervosa: 60 mg once daily. Panic Disorder: Initially 10 mg daily, increased to 20 mg daily after one week, maximum 60 mg daily. PMDD: 20 mg daily continuously or intermittently.
Elderly
Lower initial doses and slower titration may be considered (e.g., 10 mg daily initially), due to potential for decreased clearance and increased sensitivity.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Take orally, once daily in the morning, with or without food. Swallow the capsule whole with water.
Mechanism of Action
Fluoxetine selectively inhibits the reuptake of serotonin by neurons in the central nervous system. This increases the concentration of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission.
Pharmacokinetics
Onset
Clinical effects may take 2-4 weeks to become apparent.
Excretion
Excreted primarily through the kidneys (80%) and feces (15%), mainly as metabolites.
Half life
Fluoxetine: 1-3 days (acute); 4-6 days (chronic). Norfluoxetine (active metabolite): 4-16 days.
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations reached in 6-8 hours.
Metabolism
Extensively metabolized in the liver to an active metabolite, norfluoxetine, primarily by CYP2D6.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
- Hypersensitivity to fluoxetine or any component of the formulation.
- Concomitant use with thioridazine or pimozide.
Drug Interactions
MAOIs
Increased risk of serotonin syndrome.
Warfarin, NSAIDs
Increased risk of bleeding due to effects on platelet aggregation.
TCAs, Pimozide, Thioridazine
Increased plasma levels and toxicity of these drugs.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, seizures, serotonin syndrome, cardiac dysfunction, and coma. Treatment is supportive and symptomatic; ensure airway, breathing, and circulation. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fluoxetine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult your doctor.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
- Hypersensitivity to fluoxetine or any component of the formulation.
- Concomitant use with thioridazine or pimozide.
Drug Interactions
MAOIs
Increased risk of serotonin syndrome.
Warfarin, NSAIDs
Increased risk of bleeding due to effects on platelet aggregation.
TCAs, Pimozide, Thioridazine
Increased plasma levels and toxicity of these drugs.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, seizures, serotonin syndrome, cardiac dysfunction, and coma. Treatment is supportive and symptomatic; ensure airway, breathing, and circulation. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fluoxetine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Fluoxetine has undergone numerous clinical trials demonstrating its efficacy and safety for approved indications, contributing significantly to its established use in psychiatry.
Lab Monitoring
- No routine lab monitoring is generally required. However, monitor serum sodium in patients at risk of hyponatremia and liver function tests if hepatic impairment is suspected.
Doctor Notes
- Carefully monitor patients for clinical worsening, suicidality, or unusual changes in behavior, especially during the initial stages of treatment or dose changes.
- Educate patients about the importance of adherence and not discontinuing the medication abruptly.
- Consider potential drug interactions, especially with other serotonergic agents or drugs metabolized by CYP2D6.
Patient Guidelines
- Take Fluact exactly as prescribed by your doctor.
- Do not stop taking this medicine abruptly, as it may lead to withdrawal symptoms. Consult your doctor for tapering off the dose.
- It may take several weeks for the full antidepressant effect to be felt.
- Report any new or worsening symptoms of depression or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Fluact may cause dizziness, drowsiness, or blurred vision. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid alcohol consumption while taking Fluact, as it may exacerbate side effects. Maintain a healthy diet and regular exercise for overall well-being.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Fluact Brand
Other medicines available under the same brand name
