Medicine Information

Fluact

Name: Fluact
Brand: Fluact
Rating: 4.5 (117 reviews)

Capsule150 mgAntifungal (systemic)ATC: J02AC01

Generic Name

Fluconazole

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
fluact 150 mg capsule	৳ 22.00	N/A

Description

Overview of the medicine

Fluact 150 mg capsule contains Fluconazole, an antifungal medication used to treat a variety of fungal and yeast infections. It is effective against candidiasis, cryptococcosis, and certain tinea infections.

Uses & Indications

Vaginal candidiasis (acute or recurrent)

Oropharyngeal and esophageal candidiasis

Systemic candidiasis (including candidaemia, disseminated candidiasis)

Cryptococcal meningitis

Prophylaxis of fungal infections in immunocompromised patients

Tinea pedis, tinea corporis, tinea cruris, and pityriasis versicolor

Dosage

Adults

For vaginal candidiasis: 150 mg as a single oral dose. For other indications, dosage varies from 50 mg to 400 mg daily, duration depending on infection type.

Elderly

No dosage adjustment is generally required unless there is evidence of renal impairment.

Renal_impairment

For patients with creatinine clearance < 50 mL/min, the dose should be reduced by 50% after the initial loading dose.

How to Take

Take the capsule orally, with or without food. Swallow whole with water. Do not chew or crush.

Mechanism of Action

Fluconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase, which is responsible for the demethylation of lanosterol to ergosterol. Ergosterol is an essential component of the fungal cell membrane; its impaired synthesis leads to increased cellular permeability and eventual cell death, exerting a fungistatic effect.

Pharmacokinetics

Onset

Clinical effects typically observed within 24-48 hours for acute infections, but full therapeutic effect may take several days depending on the infection type and severity.

Excretion

Primarily renal; approximately 80% of the dose is excreted unchanged in the urine, and about 11% as metabolites.

Half life

Approximately 30 hours, which allows for once-daily dosing.

Absorption

Well absorbed orally, with bioavailability greater than 90% (similar to intravenous administration). Peak plasma concentrations are achieved within 0.5 to 1.5 hours.

Metabolism

Minimally metabolized; about 11% of the drug is metabolized in the liver to inactive metabolites. It is a potent inhibitor of CYP2C9 and a moderate inhibitor of CYP2C19 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to fluconazole, other azole antifungals, or any excipients of the formulation.
Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin due to risk of QT prolongation and serious arrhythmias.

Drug Interactions

Rifampin

Decreased fluconazole plasma concentrations.

Warfarin

Increased prothrombin time (PT) leading to bleeding risk.

Phenytoin

Increased phenytoin plasma concentrations.

Hydrochlorothiazide

Increased fluconazole plasma concentrations.

Benzodiazepines (e.g., midazolam)

Increased plasma levels and effects of benzodiazepines.

Cyclosporine, Tacrolimus, Sirolimus

Increased plasma levels of these immunosuppressants.

Oral Hypoglycemics (e.g., sulfonylureas)

Increased plasma concentrations and risk of hypoglycemia.

Statins (e.g., atorvastatin, simvastatin)

Increased risk of myopathy and rhabdomyolysis.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, supportive and symptomatic treatment should be initiated. Gastric lavage may be considered if appropriate. Hemodialysis can significantly reduce fluconazole plasma levels.

Pregnancy & Lactation

Pregnancy: Category D (for long-term/high-dose use) or C (single dose for vaginal candidiasis). Use during pregnancy should be avoided unless the benefits outweigh the potential risks. Lactation: Fluconazole is excreted in breast milk. Use is not recommended during breastfeeding, especially with high or repeated doses, unless strictly necessary.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 capsule per blister pack

Shelf Life

Generally 2 to 3 years from the date of manufacture. Check the expiry date on the packaging.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy and safety of fluconazole for various fungal infections across different patient populations, demonstrating its role as a standard treatment option.

Lab Monitoring

Liver function tests (LFTs) should be monitored, especially in patients with pre-existing liver conditions or receiving prolonged therapy.
Renal function tests (creatinine, BUN) if renal impairment is suspected or present.
Electrolytes, particularly potassium and magnesium, if there is a risk of QT prolongation.

Doctor Notes

Emphasize patient compliance to complete the full course of therapy to prevent relapse and development of resistance.
Counsel patients on potential drug interactions, especially with warfarin, phenytoin, and certain antiarrhythmics.
Monitor liver function tests periodically, especially in patients on prolonged therapy or with pre-existing liver disease.

Patient Guidelines

Complete the full course of treatment as prescribed, even if symptoms improve, to prevent recurrence.
Report any severe skin reactions, jaundice, or other serious side effects immediately to your doctor.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Fluconazole may cause dizziness or seizures in some individuals. Patients should be cautioned about driving or operating machinery if they experience these symptoms.

Lifestyle Advice

Maintain good hygiene, especially for skin and nail infections.
Avoid wearing tight, non-breathable clothing or footwear that can promote fungal growth.
Avoid alcohol consumption during treatment, as it may exacerbate liver side effects.

Alternative Medicines in Bangladesh

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Flugal 150 mg capsule (Square Pharmaceuticals Ltd.)Fludac 150 mg capsule (Beximco Pharmaceuticals Ltd.)Flucona 150 mg capsule (Incepta Pharmaceuticals Ltd.)Foniten 150 mg capsule (ACI Limited)