Administer orally, usually once daily in the morning, with food to minimize gastrointestinal upset.

Fludrocortisone acts as a potent mineralocorticoid, binding to mineralocorticoid receptors in the kidney tubules. This binding promotes the reabsorption of sodium and water from the renal tubules back into the blood, while simultaneously increasing the excretion of potassium and hydrogen ions. It also has some glucocorticoid effects, reducing inflammation and suppressing the immune system.

• •Systemic fungal infections (unless used in specific replacement therapy for adrenocortical insufficiency)
• •Hypersensitivity to fludrocortisone or any component of the formulation

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms of overdose include edema, hypertension, hypokalemia, and muscle weakness. Management is symptomatic and supportive, including correction of electrolyte imbalance. Discontinuation or dose reduction may be necessary.

Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Fludrocortisone is excreted in breast milk; caution should be exercised when administered to a nursing woman.