Medicine Information

Flugal

Name: Flugal
Brand: Flugal

Capsule150 mgAntifungalATC: J02AC01

Generic Name

Fluconazole 150 mg Capsule

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
flugal 150 mg capsule	৳ 22.14	৳ 221.40

Description

Overview of the medicine

Flugal 150 mg Capsule contains Fluconazole, an antifungal medication used to treat a variety of fungal infections, including vaginal candidiasis, oropharyngeal and esophageal candidiasis, and cryptococcal meningitis. It works by stopping the growth of fungi.

Uses & Indications

Vaginal candidiasis (yeast infection)

Oropharyngeal and esophageal candidiasis

Systemic candidiasis

Cryptococcal meningitis

Prophylaxis of fungal infections in immunocompromised patients

Dermatophyte infections (e.g., tinea pedis, tinea corporis)

Dosage

Adults

For vaginal candidiasis: Single oral dose of 150 mg. For other infections, dosage varies (e.g., 50-400 mg daily).

Elderly

No dose adjustment generally required unless renal function is impaired. Use caution.

Renal_impairment

Dose reduction necessary; e.g., for creatinine clearance <50 mL/min, reduce dose by 50% after initial loading dose.

How to Take

Take the capsule orally with or without food. For vaginal candidiasis, it's a single dose. For other conditions, follow your doctor's instructions.

Mechanism of Action

Fluconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase, which is responsible for converting lanosterol to ergosterol. Ergosterol is an essential component of the fungal cell membrane; its inhibition leads to increased cell membrane permeability and eventual cell lysis.

Pharmacokinetics

Onset

Clinical effects typically observed within a few days, depending on the infection type.

Excretion

Primarily excreted unchanged in the urine (approximately 80% of the dose).

Half life

Approximately 30 hours (range 20-50 hours).

Absorption

Well absorbed orally, bioavailability is >90%. Peak plasma concentrations occur within 1-2 hours.

Metabolism

Minimally metabolized; 11% of the dose is metabolized in the liver.

Side Effects

Contraindications

Hypersensitivity to Fluconazole or other azole antifungals
Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin in patients receiving multiple doses of fluconazole

Drug Interactions

Warfarin

Increased prothrombin time, increased risk of bleeding.

Phenytoin

Increased phenytoin levels, risk of toxicity.

Hydrochlorothiazide

Increases plasma concentrations of fluconazole.

Cyclosporine, Tacrolimus

Increased levels of immunosuppressants, risk of nephrotoxicity.

Oral Hypoglycemics (e.g., sulfonylureas)

Increased blood glucose lowering effect, risk of hypoglycemia.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include hallucinations and paranoid behavior. Treatment is symptomatic and supportive. Gastric lavage may be performed if indicated. Hemodialysis significantly reduces plasma levels of fluconazole.

Pregnancy & Lactation

Pregnancy Category C (single dose for vaginal candidiasis might be Category B). Chronic use in pregnancy is contraindicated due to potential teratogenic effects. Use with caution during lactation; fluconazole is excreted in breast milk.

Side Effects

Contraindications

Hypersensitivity to Fluconazole or other azole antifungals
Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin in patients receiving multiple doses of fluconazole

Drug Interactions

Warfarin

Increased prothrombin time, increased risk of bleeding.

Phenytoin

Increased phenytoin levels, risk of toxicity.

Hydrochlorothiazide

Increases plasma concentrations of fluconazole.

Cyclosporine, Tacrolimus

Increased levels of immunosuppressants, risk of nephrotoxicity.

Oral Hypoglycemics (e.g., sulfonylureas)

Increased blood glucose lowering effect, risk of hypoglycemia.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 capsule per pack2 capsules per pack

Shelf Life

Typically 2-3 years from manufacturing date

Availability

Pharmacies nationwide

Approval Status

Approved by FDA and DGDA

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Fluconazole has undergone extensive clinical trials demonstrating its efficacy and safety for various fungal infections, particularly candidiasis and cryptococcosis.

Lab Monitoring

Liver function tests (ALT, AST, ALP, bilirubin) for prolonged therapy or in patients with pre-existing liver disease
Renal function tests (creatinine, BUN) in patients with renal impairment
Electrolytes (potassium) for patients at risk of arrhythmias

Doctor Notes

Monitor liver function in patients on prolonged therapy.
Caution with patients receiving other QT-prolonging drugs.
Adjust dose for renal impairment.

Patient Guidelines

Complete the full course of medication as prescribed, even if symptoms improve.
Do not share this medication with others.
Inform your doctor about all other medications you are taking.
Report any severe side effects immediately.

Missed Dose Advice

Since Flugal 150 mg is often a single dose for vaginal candidiasis, a missed dose is not usually applicable. For multi-dose regimens, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.