Flugal
Generic Name
Flugal-50-mg-suspension
Manufacturer
PharmaLife Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| flugal 50 mg suspension | ৳ 78.53 | N/A |
Description
Overview of the medicine
Flugal 50 mg Suspension is an antifungal medication used to treat various fungal infections including candidiasis of the mouth, throat, esophagus, and vagina. It works by stopping the growth of fungi.
Uses & Indications
Dosage
Adults
For oral candidiasis: 50 mg once daily for 7-14 days. For severe or refractory cases, dosage and duration may be adjusted by a physician.
Elderly
No dosage adjustment is generally required for elderly patients with normal renal function.
Renal_impairment
Dosage should be reduced by 50% for patients with creatinine clearance <50 mL/min.
How to Take
Shake the bottle well before each use. Measure the prescribed dose using the provided measuring spoon or cup. Can be taken with or without food.
Mechanism of Action
Flugal inhibits the fungal enzyme lanosterol 14-alpha-demethylase, which is responsible for the conversion of lanosterol to ergosterol. Ergosterol is an essential component of the fungal cell membrane; its inhibition leads to increased cell membrane permeability, leakage of cellular contents, and fungal cell death.
Pharmacokinetics
Onset
Antifungal effects typically observed within 24-48 hours of treatment initiation.
Excretion
Mainly excreted unchanged in the urine (approximately 80% of dose).
Half life
Approximately 30 hours, allowing for once-daily dosing.
Absorption
Well absorbed from the gastrointestinal tract, with oral bioavailability >90%. Peak plasma concentrations achieved within 1-2 hours after administration.
Metabolism
Minimally metabolized; primarily unchanged drug excreted.
Side Effects
Contraindications
- Hypersensitivity to Flugal or other azole antifungals
- Co-administration with terfenadine, astemizole, cisapride, pimozide, or quinidine in patients receiving multiple doses of Flugal
Drug Interactions
Warfarin
May increase the anticoagulant effect, leading to an increased risk of bleeding. Monitor INR closely.
Phenytoin
May increase phenytoin serum levels, requiring dose adjustment. Monitor phenytoin levels.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be employed, including gastric lavage if appropriate. Hemodialysis may decrease plasma concentrations.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Flugal or other azole antifungals
- Co-administration with terfenadine, astemizole, cisapride, pimozide, or quinidine in patients receiving multiple doses of Flugal
Drug Interactions
Warfarin
May increase the anticoagulant effect, leading to an increased risk of bleeding. Monitor INR closely.
Phenytoin
May increase phenytoin serum levels, requiring dose adjustment. Monitor phenytoin levels.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be employed, including gastric lavage if appropriate. Hemodialysis may decrease plasma concentrations.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Flugal in various fungal infections. Post-marketing surveillance continues to monitor for rare adverse events.
Lab Monitoring
- Liver function tests (ALT, AST, alkaline phosphatase) especially in patients with pre-existing hepatic impairment or those on prolonged therapy.
- Renal function tests if needed.
Doctor Notes
- Advise patients on the importance of completing the full course of therapy to prevent relapse and resistance.
- Counsel on potential drug interactions, especially with warfarin and phenytoin.
- Monitor liver function periodically, particularly in patients with underlying liver disease.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Do not stop taking the medication abruptly.
- Shake the bottle well before each use.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Flugal may cause dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how Flugal affects them.
Lifestyle Advice
- Maintain good personal hygiene to prevent recurrence of fungal infections.
- Wear breathable clothing to reduce moisture in affected areas.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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