Flugal
Generic Name
Fluconazole 50 mg capsule
Manufacturer
Reputable Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| flugal 50 mg capsule | ৳ 8.07 | ৳ 80.70 |
Description
Overview of the medicine
Fluconazole is an antifungal medication used to treat various fungal infections. It belongs to the triazole group of antifungals.
Uses & Indications
Dosage
Adults
Vaginal Candidiasis: 150 mg single dose. Oropharyngeal Candidiasis: 50-100 mg daily for 7-14 days. Systemic Candidiasis: 400 mg on day 1, then 200-400 mg daily.
Elderly
Dosage adjustment may be necessary for renal impairment.
Renal_impairment
Dosage must be adjusted based on creatinine clearance.
How to Take
Can be taken with or without food. Swallow the capsule whole with water.
Mechanism of Action
Inhibits fungal cytochrome P450-dependent 14-alpha-demethylase, which is essential for ergosterol synthesis. This leads to increased cellular permeability and inhibition of fungal growth.
Pharmacokinetics
Onset
1-2 hours for peak plasma concentration.
Excretion
Primarily renal (approximately 80% unchanged in urine).
Half life
Approximately 30 hours.
Absorption
Well absorbed from the gastrointestinal tract, bioavailability is over 90%.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to fluconazole or other azole antifungals.
- Concomitant use with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin.
Drug Interactions
Warfarin
Increased prothrombin time; monitor INR.
Phenytoin
Increased phenytoin levels; monitor levels.
Rifampicin
Decreased fluconazole levels.
Oral Hypoglycemics
Prolonged half-life, monitor blood glucose.
Hydrochlorothiazide
Increased fluconazole levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Gastric lavage may be appropriate. Symptomatic and supportive measures, with forced diuresis, may be employed. Hemodialysis significantly decreases plasma levels.
Pregnancy & Lactation
Pregnancy: Category C (single dose for vaginal candidiasis is category B); high doses or prolonged use should be avoided unless potential benefits outweigh risks. Lactation: Fluconazole is excreted in breast milk; use with caution.
Side Effects
Contraindications
- Hypersensitivity to fluconazole or other azole antifungals.
- Concomitant use with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin.
Drug Interactions
Warfarin
Increased prothrombin time; monitor INR.
Phenytoin
Increased phenytoin levels; monitor levels.
Rifampicin
Decreased fluconazole levels.
Oral Hypoglycemics
Prolonged half-life, monitor blood glucose.
Hydrochlorothiazide
Increased fluconazole levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Gastric lavage may be appropriate. Symptomatic and supportive measures, with forced diuresis, may be employed. Hemodialysis significantly decreases plasma levels.
Pregnancy & Lactation
Pregnancy: Category C (single dose for vaginal candidiasis is category B); high doses or prolonged use should be avoided unless potential benefits outweigh risks. Lactation: Fluconazole is excreted in breast milk; use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established its efficacy and safety profile for various fungal infections.
Lab Monitoring
- Liver function tests (baseline and periodically, especially with long-term use).
- Renal function (creatinine clearance).
- Electrolytes (if prolonged QT interval is a concern).
Doctor Notes
- Counsel patients on completing the full course.
- Monitor LFTs if used long term or in patients with pre-existing liver conditions.
- Consider drug interactions, especially with CYP2C9/2C19/3A4 substrates.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Complete the full course of treatment, even if symptoms improve.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some individuals. Exercise caution when driving or operating machinery until you know how Fluconazole affects you.
Lifestyle Advice
- Maintain good hygiene to prevent recurrence of fungal infections.
- Avoid sharing personal items like towels or clothing.
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