Fluking
Generic Name
Flubendazole 125 mg suspension
Manufacturer
MediCorp Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fluking 125 mg suspension | ৳ 50.00 | N/A |
Description
Overview of the medicine
Fluking 125 mg Suspension is an anthelmintic medication used to treat a variety of worm infections in the intestines, such as roundworms, hookworms, whipworms, and pinworms. It works by preventing the worms from absorbing sugar, which depletes their energy and eventually kills them.
Uses & Indications
Dosage
Adults
For most intestinal worm infections: 125 mg (5 ml) twice daily for 3 days. For pinworm: A single dose of 125 mg (5 ml). Repeat after 2-4 weeks if necessary.
Elderly
No specific dose adjustment required based on age, same as adult dose.
Renal_impairment
No dose adjustment necessary as systemic absorption is minimal.
How to Take
Shake the suspension well before use. It can be taken with or without food. For young children, it can be mixed with food or liquids.
Mechanism of Action
Flubendazole selectively binds to tubulin, a structural protein of microtubules, in the intestinal cells of parasitic worms. This binding inhibits microtubule polymerization, leading to the disruption of the worms' glucose uptake and energy metabolism, eventually causing paralysis and death of the worm.
Pharmacokinetics
Onset
Anthelmintic effects are observed within a few days of treatment completion.
Excretion
Mainly excreted unchanged in the feces. A small portion of metabolites is excreted in urine.
Half life
Approximately 1.5 to 2.5 hours (systemically absorbed fraction).
Absorption
Poorly absorbed from the gastrointestinal tract (less than 10% bioavailability). Absorption may be slightly increased with fatty meals.
Metabolism
Undergoes extensive first-pass metabolism in the liver.
Side Effects
Contraindications
- Hypersensitivity to Flubendazole or any component of the formulation
- Pregnancy (relative contraindication, consult physician)
Drug Interactions
Ritonavir
May alter Flubendazole levels.
Cimetidine
May inhibit the metabolism of Flubendazole, potentially leading to increased plasma concentrations (though systemic absorption is low).
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, gastrointestinal symptoms like abdominal cramps, nausea, vomiting, and diarrhea may occur. Treatment is symptomatic and supportive. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is unknown if Flubendazole is excreted in human milk; use with caution during breastfeeding. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Flubendazole or any component of the formulation
- Pregnancy (relative contraindication, consult physician)
Drug Interactions
Ritonavir
May alter Flubendazole levels.
Cimetidine
May inhibit the metabolism of Flubendazole, potentially leading to increased plasma concentrations (though systemic absorption is low).
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, gastrointestinal symptoms like abdominal cramps, nausea, vomiting, and diarrhea may occur. Treatment is symptomatic and supportive. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is unknown if Flubendazole is excreted in human milk; use with caution during breastfeeding. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of Flubendazole in treating various helminthic infections. Studies generally show high cure rates and good tolerability.
Lab Monitoring
- No routine lab monitoring is generally required for typical short-term use.
- Liver function tests (LFTs) and complete blood count (CBC) may be considered in cases of prolonged therapy or suspected adverse reactions.
Doctor Notes
- Advise patients on proper hygiene to prevent re-infection, especially for pinworms.
- Emphasize completion of the full course of treatment.
- Consider treating household contacts for pinworm infections.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Practice good hygiene (e.g., wash hands thoroughly) to prevent re-infection.
- Do not share this medication with others.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Fluking is generally not expected to impair the ability to drive or operate machinery. However, if you experience dizziness, avoid such activities.
Lifestyle Advice
- Maintain personal hygiene, especially hand washing before meals and after using the toilet.
- Ensure proper sanitation and clean drinking water to prevent re-infection.
- Keep nails short to reduce the risk of pinworm re-infection.
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Global Brand Names
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