Fluking
Generic Name
Praziquantel
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fluking 250 mg capsule | ৳ 5.50 | ৳ 22.00 |
Description
Overview of the medicine
Fluking 250 mg Capsule contains Praziquantel, an anthelmintic agent used for the treatment of various trematode (fluke) and cestode (tapeworm) infections. It works by causing severe spasms and paralysis of the worms' musculature, leading to their detachment from host tissue and subsequent elimination from the body.
Uses & Indications
Dosage
Adults
The dosage varies depending on the type of infection. For Schistosomiasis: 40 mg/kg as a single dose or divided into two doses. For Clonorchiasis/Opisthorchiasis: 25 mg/kg three times daily for 1-3 days. For Taeniasis: 10-20 mg/kg as a single dose.
Elderly
No specific dose adjustment is generally required for elderly patients, but caution should be exercised due to potential age-related decrease in renal or hepatic function.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment. For severe renal impairment, dose reduction may be considered due to potential accumulation of metabolites.
How to Take
Take the capsule whole with water, preferably with food to minimize gastrointestinal discomfort. Do not chew or crush the capsule.
Mechanism of Action
Praziquantel increases the permeability of the cell membranes of susceptible worms to calcium ions. This leads to massive contractions and paralysis of the musculature of the worms. The worms detach from the host's blood vessels and are then cleared from the body by immune responses or passage through the digestive system.
Pharmacokinetics
Onset
Within hours of administration, visible effects on worms may be observed.
Excretion
Mainly excreted in the urine (70-80%) and to a lesser extent in feces (10-20%) as metabolites.
Half life
Approximately 1-2.5 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations achieved within 1-3 hours.
Metabolism
Extensively metabolized in the liver, primarily via cytochrome P450 enzymes (mainly CYP3A4), to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Praziquantel or any component of the formulation.
- Ocular cysticercosis (due to potential irreversible eye damage).
- Co-administration with strong CYP3A4 inducers (e.g., Rifampicin).
Drug Interactions
Rifampicin
Significantly decreases praziquantel plasma levels, reducing its therapeutic effect. Co-administration is contraindicated.
Phenytoin, Carbamazepine, Dexamethasone
May decrease praziquantel plasma concentrations.
Cimetidine, Ketoconazole, Grapefruit Juice
May increase praziquantel plasma concentrations.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, abdominal pain, diarrhea, and dizziness. Treatment is symptomatic and supportive. Gastric lavage may be considered if recent ingestion.
Pregnancy & Lactation
Praziquantel is generally considered safe during pregnancy, especially in the second and third trimesters, when the benefits outweigh the risks. It is excreted in human milk; use with caution in breastfeeding mothers, or consider temporary interruption of breastfeeding for 72 hours after treatment.
Side Effects
Contraindications
- Hypersensitivity to Praziquantel or any component of the formulation.
- Ocular cysticercosis (due to potential irreversible eye damage).
- Co-administration with strong CYP3A4 inducers (e.g., Rifampicin).
Drug Interactions
Rifampicin
Significantly decreases praziquantel plasma levels, reducing its therapeutic effect. Co-administration is contraindicated.
Phenytoin, Carbamazepine, Dexamethasone
May decrease praziquantel plasma concentrations.
Cimetidine, Ketoconazole, Grapefruit Juice
May increase praziquantel plasma concentrations.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, abdominal pain, diarrhea, and dizziness. Treatment is symptomatic and supportive. Gastric lavage may be considered if recent ingestion.
Pregnancy & Lactation
Praziquantel is generally considered safe during pregnancy, especially in the second and third trimesters, when the benefits outweigh the risks. It is excreted in human milk; use with caution in breastfeeding mothers, or consider temporary interruption of breastfeeding for 72 hours after treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Praziquantel has been extensively studied in numerous clinical trials globally, confirming its efficacy and safety for parasitic worm infections. Further trials may explore new indications or formulations.
Lab Monitoring
- Liver function tests (LFTs) may be monitored in patients with pre-existing hepatic impairment.
- No routine laboratory monitoring is generally required for healthy individuals.
Doctor Notes
- Advise patients to report any severe abdominal pain, high fever, or allergic reactions immediately.
- Ensure patient understanding of the importance of hygiene to prevent re-infection.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if you feel better.
- Take the capsule with food to reduce stomach upset.
- Avoid driving or operating heavy machinery if you experience dizziness or drowsiness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or drowsiness. Patients should be advised to exercise caution when driving or operating machinery until they know how Praziquantel affects them.
Lifestyle Advice
- Practice good hygiene, including frequent handwashing, to prevent reinfection.
- Ensure proper sanitation and avoid consuming contaminated food or water.
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Global Brand Names
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